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- W4386772355 abstract "This chapter looks at other important common drug targets in medicinal chemistry which illustrate the variety of ways in which drugs can act. It discusses transport proteins which carry polar molecules across the hydrophobic cell membrane. It also explores how drugs can be designed to take advantage of the transport system in order to gain access to cells or to block transport protein. The chapter also describes tubulin as a structural protein and show that this is crucial to cell division and cell mobility and is the target for several anticancer drugs. The chapter examines the vinca alkaloids that bind to tubulin and inhibit the polymerization process. It emphasizes how carbohydrates are more difficult to synthesize than peptides as they offer a greater variety of potential novel structures." @default.
- W4386772355 created "2023-09-16" @default.
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- W4386772355 date "2023-03-16" @default.
- W4386772355 modified "2023-09-26" @default.
- W4386772355 title "Miscellaneous drug targets" @default.
- W4386772355 doi "https://doi.org/10.1093/hesc/9780198866664.003.0012" @default.
- W4386772355 hasPublicationYear "2023" @default.
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