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- W4386772923 abstract "This chapter addresses the optimization of lead compounds. Once a lead compound has been identified, from whatever source, the next step in the drug design and development process is the optimization of this lead compound. There are two main aspects to this optimization process: improvement in the interaction of the molecule with the appropriate drug target (pharmacodynamics) and improvement in the ability of the molecule to be available to that target (pharmacokinetics). These two processes are carried out simultaneously because it would be pointless identifying a molecule that is highly active at the target only to find that it cannot be absorbed or is very rapidly metabolized. During this improvement process, <italic>in vitro</italic> (and possibly <italic>in vivo</italic>) testing will continue on any molecules so produced in order to further inform the optimization process." @default.
- W4386772923 created "2023-09-16" @default.
- W4386772923 creator A5067472247 @default.
- W4386772923 date "2020-08-20" @default.
- W4386772923 modified "2023-09-27" @default.
- W4386772923 title "Optimization of Lead Compounds" @default.
- W4386772923 doi "https://doi.org/10.1093/hesc/9780198749318.003.0010" @default.
- W4386772923 hasPublicationYear "2020" @default.
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