Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386773345> ?p ?o ?g. }
Showing items 1 to 50 of
50
with 100 items per page.
- W4386773345 abstract "This chapter looks at an early example of how the strategies of <italic>de novo</italic> drug design and structure-based drug design were used together to develop an active compound which went forward for clinical trials. It reviews the research involved i the design of inhibitors for the enzyme thymidylate synthase. It also explains how thymidylate synthase catalyses the methylation of deoxyuridylate monophosphate (dUMP) to deoxythymidylate monophosphate (dTMP) using 5, 10-methylenetetrahydrofolate as a coenzyme. The chapter describes inhibitors which are structurally related to the natural substrate and cofactor. It explores the use of the <italic>de novo</italic> drug to design a novel structure unrelated to natural substrates." @default.
- W4386773345 created "2023-09-16" @default.
- W4386773345 creator A5041255871 @default.
- W4386773345 date "2023-03-16" @default.
- W4386773345 modified "2023-09-26" @default.
- W4386773345 title "Design of a thymidylate synthase inhibitor" @default.
- W4386773345 doi "https://doi.org/10.1093/hesc/9780198866664.003.0028" @default.
- W4386773345 hasPublicationYear "2023" @default.
- W4386773345 type Work @default.
- W4386773345 citedByCount "0" @default.
- W4386773345 crossrefType "book-chapter" @default.
- W4386773345 hasAuthorship W4386773345A5041255871 @default.
- W4386773345 hasConcept C121608353 @default.
- W4386773345 hasConcept C123321153 @default.
- W4386773345 hasConcept C181199279 @default.
- W4386773345 hasConcept C185592680 @default.
- W4386773345 hasConcept C197957613 @default.
- W4386773345 hasConcept C2780456651 @default.
- W4386773345 hasConcept C54355233 @default.
- W4386773345 hasConcept C55493867 @default.
- W4386773345 hasConcept C70721500 @default.
- W4386773345 hasConcept C71240020 @default.
- W4386773345 hasConcept C86803240 @default.
- W4386773345 hasConceptScore W4386773345C121608353 @default.
- W4386773345 hasConceptScore W4386773345C123321153 @default.
- W4386773345 hasConceptScore W4386773345C181199279 @default.
- W4386773345 hasConceptScore W4386773345C185592680 @default.
- W4386773345 hasConceptScore W4386773345C197957613 @default.
- W4386773345 hasConceptScore W4386773345C2780456651 @default.
- W4386773345 hasConceptScore W4386773345C54355233 @default.
- W4386773345 hasConceptScore W4386773345C55493867 @default.
- W4386773345 hasConceptScore W4386773345C70721500 @default.
- W4386773345 hasConceptScore W4386773345C71240020 @default.
- W4386773345 hasConceptScore W4386773345C86803240 @default.
- W4386773345 hasLocation W43867733451 @default.
- W4386773345 hasOpenAccess W4386773345 @default.
- W4386773345 hasPrimaryLocation W43867733451 @default.
- W4386773345 hasRelatedWork W1164537646 @default.
- W4386773345 hasRelatedWork W169735115 @default.
- W4386773345 hasRelatedWork W2029709235 @default.
- W4386773345 hasRelatedWork W2080203695 @default.
- W4386773345 hasRelatedWork W2084240653 @default.
- W4386773345 hasRelatedWork W2089807857 @default.
- W4386773345 hasRelatedWork W2170874906 @default.
- W4386773345 hasRelatedWork W2806378807 @default.
- W4386773345 hasRelatedWork W2925386497 @default.
- W4386773345 hasRelatedWork W950805422 @default.
- W4386773345 isParatext "false" @default.
- W4386773345 isRetracted "false" @default.
- W4386773345 workType "book-chapter" @default.