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- W4386774273 abstract "This chapter considers what happens once a receptor has been activated, noting that the interaction of a receptor with its chemical messenger is the first step in a complex chain of events involving several secondary messengers which lead to a change in cell chemistry. The chapter explains the methodology behind signal transduction pathways which follow the activation of G-protein-coupled receptors (GPCRs). It notes that 30% of all drugs on the market interact with these kinds of receptor. It also talks about transduction pathways for kinase receptors and shows that these offer new targets for novel drugs, particularly in the area of anticancer therapy. The chapter describes the signalling cascade initiated by receptor–ligand binding which results in substantial signal amplification, which does not require the original chemical messenger to enter the cell. It examines kinases and illustrates that these are involved in the desensitization of receptors." @default.
- W4386774273 created "2023-09-16" @default.
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- W4386774273 date "2023-03-16" @default.
- W4386774273 modified "2023-09-26" @default.
- W4386774273 title "Receptors and signal transduction" @default.
- W4386774273 doi "https://doi.org/10.1093/hesc/9780198866664.003.0006" @default.
- W4386774273 hasPublicationYear "2023" @default.
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