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- W4386774476 abstract "This chapter concentrates on the mechanism of the action of drugs which target nucleic acids in the areas of antibacterial and anticancer therapy. It considers drugs that interact with DNA and shows how these categorized into intercalating agents, topoisomerase poisons, alkylating agents, chain cutters, and chain terminators. It also highlights intercalating drugs which contain planar aromatic or heteroaromatic ring systems that can slide between the base pairs of the DNA double helix. The chapter looks at bleomycins, which are intercalating drugs that form complexes with ferrous ions and generate reactive oxygen species. These cleave the strands of DNA. The chapter considers etoposide and teniposide as non-intercalating drugs which act as topoisomerase II poisons." @default.
- W4386774476 created "2023-09-16" @default.
- W4386774476 creator A5041255871 @default.
- W4386774476 date "2023-03-16" @default.
- W4386774476 modified "2023-09-26" @default.
- W4386774476 title "Nucleic acids as drug targets" @default.
- W4386774476 doi "https://doi.org/10.1093/hesc/9780198866664.003.0011" @default.
- W4386774476 hasPublicationYear "2023" @default.
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