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- W4386775283 abstract "Autophagic lysosome reformation (ALR) is a crucial cellular process that involves regenerating lysosomes from the existing autolysosomes. ALR shares an inverse correlation with the autophagy machinery. As autophagy depletes the lysosomal pool, ALR recovers the lost lysosomes and provides the nascent small lysosomes into the pool to maintain lysosomal homeostasis. ALR involves the recruitment of the molecular machinery to the microdomain of autolysosomes from where the tubule is formed in the form of a bud. Then the tubule is elongated and cut off to form the proto-lysosomes. These newly formed proto-lysosomes then mature to form the active functional lysosomes readily available for autophagy. In this chapter, the authors discuss the updated molecular events during ALR progression and its physiological relevance in different conditions, providing a new insight into future therapeutics in autophagy and lysosome-related diseases." @default.
- W4386775283 created "2023-09-16" @default.
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- W4386775283 date "2024-01-01" @default.
- W4386775283 modified "2023-09-27" @default.
- W4386775283 title "Autophagic lysosome reformation: The beginning from the end" @default.
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- W4386775283 doi "https://doi.org/10.1016/b978-0-323-90142-0.00009-8" @default.
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