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- W4386775657 abstract "Cadmium (Cd) is retained in the kidneys in large amounts thus inducing oxidative damage. Vitamin D (VD) is a potent antioxidant that is postulated to reverse the Cd-induced oxidative effects. The present study aimed at investigating the effect of VD administration on reversing Cd-induced renal toxicity. Twenty-four male rats were assorted into three equal groups: Negative control (NC) group receiving drinking water only, Positive control (PC) group receiving Cadmium chloride (CdCl2) and VD group receiving VD injections in addition to CdCl2. The serum levels of creatinine, urea and 25-OH VD as well as renal tissue concentration of glutathione peroxidase (GPX) and malondialdehyde (MDA) were measured. Tissue sections were examined for signs of renal injury, immunostained for Vitamin D receptor (VDR), Cyp24a1 and Cyp27b1 and the apoptotic index was measured. Cd administration resulted in higher serum levels of creatinine and urea as well as lower serum 25-OH VD level in addition to higher MDA and lower GPX renal concentration. VD supplementation showed improved renal functions, a remarkable improvement in the renal tissue with enhanced expression of VDR and Cyp27b1, lower Cyp24a1 expression and a lower apoptotic index. VD administration can ameliorate Cd-induced nephrotoxicity." @default.
- W4386775657 created "2023-09-16" @default.
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- W4386775657 date "2023-12-01" @default.
- W4386775657 modified "2023-09-26" @default.
- W4386775657 title "The protective effects of Vitamin D against Cadmium-induced nephrotoxicity" @default.
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- W4386775657 doi "https://doi.org/10.1016/j.jtemin.2023.100097" @default.
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