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- W4386776966 abstract "This chapter elaborates on the overview presented in Chapter 3. Gene regulatory networks are complex systems that control the expression of genes in response to environmental cues. These networks can be quantified by looking at how the network elements interact with each other, and how the network elements can be tuned to optimize a desired outcome. Trade-offs between different forms of regulation can be quantified by looking at the effects on gene expression, or the number of regulatory proteins needed to achieve a desired outcome; trade-offs between different types of regulatory strategies can be quantified by looking at the efficiency of the network; that is, how well the system controlled by the network is able to respond to environmental changes, and how much energy and other resources are needed to maintain the network. This chapter necessarily deals with the interactome—the network of protein–protein and protein–nucleic acid interactions—that underpin the regulatory networks. Biophysicochemical aspects of the interactions, including specificity and cooperative binding, are discussed, followed by an account of the various in vivo and in vitro (including chromatography and biosensing) experimental methods that can be used to gather the primary data on interactions, from which interactomic inferences may follow. Network modelling is covered, including analysis of an operon. Data collection and analysis of metabolism (the metabolome) is covered, including metabolic control analysis." @default.
- W4386776966 created "2023-09-16" @default.
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- W4386776966 date "2023-01-01" @default.
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- W4386776966 title "Regulatory Networks" @default.
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- W4386776966 doi "https://doi.org/10.1007/978-3-030-45607-8_23" @default.
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