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- W4386779565 abstract "Attention deficit-hyperactivity disorder (ADHD) is a neurodevelopmental disorder with high incidence in children and adolescents characterized by motor hyperactivity, impulsivity, and inattention. Magnetic resonance imaging (MRI) has revealed that neuroanatomical abnormalities such as the volume reduction in the neocortex and hippocampus are shared by several neuropsychiatric diseases such as schizophrenia, autism spectrum disorder and ADHD. Furthermore, the abnormal development and postnatal pruning of dendritic spines of neocortical neurons in schizophrenia, autism spectrum disorder and intellectual disability are well documented. Dendritic spines are dynamic structures exhibiting Hebbian and homeostatic plasticity that triggers intracellular cascades involving glutamate receptors, calcium influx and remodeling of the F-actin network. The long-term potentiation (LTP)-induced insertion of postsynaptic glutamate receptors is associated with the enlargement of spine heads and long-term depression (LTD) with spine shrinkage. Using a murine model of ADHD, a delay in dendritic spines' maturation in CA1 hippocampal neurons correlated with impaired working memory and hippocampal LTP has recently reported. The aim of this review is to summarize recent evidence that has emerged from studies focused on the neuroanatomical and genetic features found in ADHD patients as well as reports from animal models describing the molecular structure and remodeling of dendritic spines." @default.
- W4386779565 created "2023-09-16" @default.
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- W4386779565 date "2023-09-15" @default.
- W4386779565 modified "2023-10-14" @default.
- W4386779565 title "Attention Deficit-Hyperactivity Disorder (ADHD): From Abnormal Behavior to Impairment in Synaptic Plasticity" @default.
- W4386779565 cites W1440335865 @default.
- W4386779565 cites W1655792606 @default.
- W4386779565 cites W1798313689 @default.
- W4386779565 cites W1966155655 @default.
- W4386779565 cites W1979019425 @default.
- W4386779565 cites W1983553517 @default.
- W4386779565 cites W1984719574 @default.
- W4386779565 cites W1987000412 @default.
- W4386779565 cites W1991926863 @default.
- W4386779565 cites W1993536619 @default.
- W4386779565 cites W1998708235 @default.
- W4386779565 cites W2008682443 @default.
- W4386779565 cites W2019124038 @default.
- W4386779565 cites W2019523818 @default.
- W4386779565 cites W2024694517 @default.
- W4386779565 cites W2027221598 @default.
- W4386779565 cites W2029815010 @default.
- W4386779565 cites W2032658084 @default.
- W4386779565 cites W2035247507 @default.
- W4386779565 cites W2040268226 @default.
- W4386779565 cites W2046033738 @default.
- W4386779565 cites W2052415426 @default.
- W4386779565 cites W2063202219 @default.
- W4386779565 cites W2074716636 @default.
- W4386779565 cites W2078311949 @default.
- W4386779565 cites W2080351494 @default.
- W4386779565 cites W2080640632 @default.
- W4386779565 cites W2097808036 @default.
- W4386779565 cites W2098917165 @default.
- W4386779565 cites W2115518880 @default.
- W4386779565 cites W2133470905 @default.
- W4386779565 cites W2137395087 @default.
- W4386779565 cites W2138613917 @default.
- W4386779565 cites W2139238342 @default.
- W4386779565 cites W2145255740 @default.
- W4386779565 cites W2146264275 @default.
- W4386779565 cites W2153614880 @default.
- W4386779565 cites W2156645869 @default.
- W4386779565 cites W2159881136 @default.
- W4386779565 cites W2166279530 @default.
- W4386779565 cites W2171612971 @default.
- W4386779565 cites W2255138985 @default.
- W4386779565 cites W2331277849 @default.
- W4386779565 cites W2335818909 @default.
- W4386779565 cites W2525665487 @default.
- W4386779565 cites W2589105429 @default.
- W4386779565 cites W2738122322 @default.
- W4386779565 cites W2760721217 @default.
- W4386779565 cites W2792523657 @default.
- W4386779565 cites W2802815532 @default.
- W4386779565 cites W2886298463 @default.
- W4386779565 cites W2889177916 @default.
- W4386779565 cites W2898344414 @default.
- W4386779565 cites W2903607699 @default.
- W4386779565 cites W2903689387 @default.
- W4386779565 cites W2906908462 @default.
- W4386779565 cites W2921286344 @default.
- W4386779565 cites W2969948459 @default.
- W4386779565 cites W2991582092 @default.
- W4386779565 cites W2992395685 @default.
- W4386779565 cites W3005461493 @default.
- W4386779565 cites W3012009865 @default.
- W4386779565 cites W3025642838 @default.
- W4386779565 cites W3034798869 @default.
- W4386779565 cites W3040646360 @default.
- W4386779565 cites W3080158422 @default.
- W4386779565 cites W3082326031 @default.
- W4386779565 cites W3084409057 @default.
- W4386779565 cites W3094181094 @default.
- W4386779565 cites W3114419121 @default.
- W4386779565 cites W3121885429 @default.
- W4386779565 cites W3128855809 @default.
- W4386779565 cites W3132088562 @default.
- W4386779565 cites W3174588745 @default.
- W4386779565 cites W3179469168 @default.
- W4386779565 cites W3194665693 @default.
- W4386779565 cites W3202114531 @default.
- W4386779565 cites W3203602359 @default.
- W4386779565 cites W3204722966 @default.
- W4386779565 cites W3205906848 @default.
- W4386779565 cites W3210166012 @default.
- W4386779565 cites W3215705196 @default.
- W4386779565 cites W3217454502 @default.