Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386780704> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W4386780704 abstract "Children with decompensated cirrhosis (DC) awaiting LT suffer from infection linked to high pediatric end-stage liver disease (PELD) scores and mortality. Granulocyte colony-stimulating factor (G-CSF) therapy has shown promising results in adult DC. Our study investigated G-CSF as an optimizing treatment for pre-transplant DC, exploring its effect on cytokine activity.An open-label, randomized controlled trial included DC patients aged 3 months-12 years. The intervention group (n=26) received 12 G-CSF courses injected subcutaneously (5 μg/kg/day) plus DC standard medical treatment (SMT). The control group (n=24) received SMT. We obtained PELD scores, tumor necrosis factor (TNF)-α, interleukin (IL)-10, hepatocyte growth factor (HGF), CD34+ mobilization, liver function, leukocyte and neutrophil counts. Infection and side effects were documented.There was no significant difference in PELD scores between the groups after 3 months G-CSF treatment. Decreased TNF-⍺ (p < 0.001) and increased IL-10 and HGF (p = 0.003 for both markers) were shown 1 month following G-CSF treatment. Alanine aminotransferase (ALT) levels improved significantly (p = 0.038). Significant increase in leucocyte and neutrophil counts (p < 0.001) and a lower incidence of sepsis (p = 0.04) were shown after intervention. There was no significant difference in survival (p = 0.372).Following 3 months of G-CSF treatment, PELD scores did not show significant improvement. G-CSF reversed the cytokine profiles in DC, resulting in reduced TNF-⍺ and increased IL-10. HGF significantly improved, indicating hepatic regeneration. Significantly decreased occurrence of sepsis following G-CSF treatment indicated improved clinical outcome." @default.
- W4386780704 created "2023-09-16" @default.
- W4386780704 creator A5011366862 @default.
- W4386780704 creator A5038807888 @default.
- W4386780704 creator A5048307424 @default.
- W4386780704 creator A5055501401 @default.
- W4386780704 creator A5067349056 @default.
- W4386780704 creator A5069059417 @default.
- W4386780704 creator A5075462900 @default.
- W4386780704 creator A5089043231 @default.
- W4386780704 date "2023-09-01" @default.
- W4386780704 modified "2023-09-26" @default.
- W4386780704 title "Granulocyte Colony-Stimulating Factor Improves Innate Immunity In Pediatric Pretransplant Patients" @default.
- W4386780704 cites W1973935677 @default.
- W4386780704 cites W2002391829 @default.
- W4386780704 cites W2063368082 @default.
- W4386780704 cites W2087528335 @default.
- W4386780704 cites W2087661498 @default.
- W4386780704 cites W2091600198 @default.
- W4386780704 cites W2104554139 @default.
- W4386780704 cites W2130703401 @default.
- W4386780704 cites W2177650810 @default.
- W4386780704 cites W2264598575 @default.
- W4386780704 cites W2513675909 @default.
- W4386780704 cites W2595193926 @default.
- W4386780704 cites W2759457207 @default.
- W4386780704 cites W2767547629 @default.
- W4386780704 cites W2780700845 @default.
- W4386780704 cites W2809840981 @default.
- W4386780704 cites W2917277724 @default.
- W4386780704 cites W2947987925 @default.
- W4386780704 cites W2981608229 @default.
- W4386780704 cites W3015110666 @default.
- W4386780704 cites W3036526002 @default.
- W4386780704 cites W3196381976 @default.
- W4386780704 cites W4280629480 @default.
- W4386780704 cites W4312905793 @default.
- W4386780704 doi "https://doi.org/10.1016/j.jceh.2023.09.003" @default.
- W4386780704 hasPublicationYear "2023" @default.
- W4386780704 type Work @default.
- W4386780704 citedByCount "0" @default.
- W4386780704 crossrefType "journal-article" @default.
- W4386780704 hasAuthorship W4386780704A5011366862 @default.
- W4386780704 hasAuthorship W4386780704A5038807888 @default.
- W4386780704 hasAuthorship W4386780704A5048307424 @default.
- W4386780704 hasAuthorship W4386780704A5055501401 @default.
- W4386780704 hasAuthorship W4386780704A5067349056 @default.
- W4386780704 hasAuthorship W4386780704A5069059417 @default.
- W4386780704 hasAuthorship W4386780704A5075462900 @default.
- W4386780704 hasAuthorship W4386780704A5089043231 @default.
- W4386780704 hasBestOaLocation W43867807041 @default.
- W4386780704 hasConcept C126322002 @default.
- W4386780704 hasConcept C170493617 @default.
- W4386780704 hasConcept C17991360 @default.
- W4386780704 hasConcept C203014093 @default.
- W4386780704 hasConcept C2776694085 @default.
- W4386780704 hasConcept C2776996007 @default.
- W4386780704 hasConcept C2777214474 @default.
- W4386780704 hasConcept C2777767877 @default.
- W4386780704 hasConcept C2778384902 @default.
- W4386780704 hasConcept C2778690821 @default.
- W4386780704 hasConcept C71924100 @default.
- W4386780704 hasConcept C90924648 @default.
- W4386780704 hasConceptScore W4386780704C126322002 @default.
- W4386780704 hasConceptScore W4386780704C170493617 @default.
- W4386780704 hasConceptScore W4386780704C17991360 @default.
- W4386780704 hasConceptScore W4386780704C203014093 @default.
- W4386780704 hasConceptScore W4386780704C2776694085 @default.
- W4386780704 hasConceptScore W4386780704C2776996007 @default.
- W4386780704 hasConceptScore W4386780704C2777214474 @default.
- W4386780704 hasConceptScore W4386780704C2777767877 @default.
- W4386780704 hasConceptScore W4386780704C2778384902 @default.
- W4386780704 hasConceptScore W4386780704C2778690821 @default.
- W4386780704 hasConceptScore W4386780704C71924100 @default.
- W4386780704 hasConceptScore W4386780704C90924648 @default.
- W4386780704 hasFunder F4320319804 @default.
- W4386780704 hasFunder F4320325829 @default.
- W4386780704 hasLocation W43867807041 @default.
- W4386780704 hasOpenAccess W4386780704 @default.
- W4386780704 hasPrimaryLocation W43867807041 @default.
- W4386780704 hasRelatedWork W1494014013 @default.
- W4386780704 hasRelatedWork W1994050787 @default.
- W4386780704 hasRelatedWork W2006549602 @default.
- W4386780704 hasRelatedWork W2031853353 @default.
- W4386780704 hasRelatedWork W2078182053 @default.
- W4386780704 hasRelatedWork W2106530602 @default.
- W4386780704 hasRelatedWork W2127733257 @default.
- W4386780704 hasRelatedWork W2398878426 @default.
- W4386780704 hasRelatedWork W2406266228 @default.
- W4386780704 hasRelatedWork W563090747 @default.
- W4386780704 isParatext "false" @default.
- W4386780704 isRetracted "false" @default.
- W4386780704 workType "article" @default.