FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386780912> ?p ?o ?g. }

• W4386780912 abstract "<div>AbstractPurpose:<p>Myelofibrosis (MF) is a clonal myeloproliferative neoplasm characterized by systemic symptoms, cytopenias, organomegaly, and bone marrow fibrosis. JAK2 inhibitors afford symptom and spleen burden reduction but do not alter the disease course and frequently lead to thrombocytopenia. TGFβ, a pleiotropic cytokine elaborated by the MF clone, negatively regulates normal hematopoiesis, downregulates antitumor immunity, and promotes bone marrow fibrosis. Our group previously showed that AVID200, a potent and selective TGFβ 1/3 trap, reduced TGFβ1-induced proliferation of human mesenchymal stromal cells, phosphorylation of SMAD2, and collagen expression. Moreover, treatment of MF mononuclear cells with AVID200 led to increased numbers of progenitor cells (PC) with wild-type JAK2 rather than JAK2V617F.</p>Patients and Methods:<p>We conducted an investigator-initiated, multicenter, phase Ib trial of AVID200 monotherapy in 21 patients with advanced MF.</p>Results:<p>No dose-limiting toxicity was identified at the three dose levels tested, and grade 3/4 anemia and thrombocytopenia occurred in 28.6% and 19.0% of treated patients, respectively. After six cycles of therapy, two patients attained a clinical benefit by IWG-MRT criteria. Spleen and symptom benefits were observed across treatment cycles. Unlike other MF-directed therapies, increases in platelet counts were noted in 81% of treated patients with three patients achieving normalization. Treatment with AVID200 resulted in potent suppression of plasma TGFβ1 levels and pSMAD2 in MF cells.</p>Conclusions:<p>AVID200 is a well-tolerated, rational, therapeutic agent for the treatment of patients with MF and should be evaluated further in patients with thrombocytopenic MF in combination with agents that target aberrant MF intracellular signaling pathways.</p></div>" @default.
• W4386780912 created "2023-09-16" @default.
• W4386780912 creator A5006337219 @default.
• W4386780912 creator A5006372952 @default.
• W4386780912 creator A5011529063 @default.
• W4386780912 creator A5011736892 @default.
• W4386780912 creator A5011897595 @default.
• W4386780912 creator A5013929903 @default.
• W4386780912 creator A5014431719 @default.
• W4386780912 creator A5015365039 @default.
• W4386780912 creator A5015888636 @default.
• W4386780912 creator A5023728016 @default.
• W4386780912 creator A5034181399 @default.
• W4386780912 creator A5035746810 @default.
• W4386780912 creator A5038693643 @default.
• W4386780912 creator A5039057642 @default.
• W4386780912 creator A5042829932 @default.
• W4386780912 creator A5046772202 @default.
• W4386780912 creator A5047764826 @default.
• W4386780912 creator A5050368246 @default.
• W4386780912 creator A5055163444 @default.
• W4386780912 creator A5057941081 @default.
• W4386780912 creator A5060907157 @default.
• W4386780912 creator A5060982517 @default.
• W4386780912 creator A5065098368 @default.
• W4386780912 creator A5067297056 @default.
• W4386780912 creator A5069624084 @default.
• W4386780912 creator A5071257161 @default.
• W4386780912 creator A5072336042 @default.
• W4386780912 creator A5074844653 @default.
• W4386780912 creator A5077063317 @default.
• W4386780912 creator A5077103444 @default.
• W4386780912 creator A5079969736 @default.
• W4386780912 creator A5081650701 @default.
• W4386780912 creator A5087995871 @default.
• W4386780912 creator A5090009905 @default.
• W4386780912 date "2023-09-15" @default.
• W4386780912 modified "2023-09-26" @default.
• W4386780912 title "Data from A Phase Ib Trial of AVID200, a TGFβ 1/3 Trap, in Patients with Myelofibrosis" @default.
• W4386780912 doi "https://doi.org/10.1158/1078-0432.c.6771815.v2" @default.
• W4386780912 hasPublicationYear "2023" @default.
• W4386780912 type Work @default.
• W4386780912 citedByCount "0" @default.
• W4386780912 crossrefType "posted-content" @default.
• W4386780912 hasAuthorship W4386780912A5006337219 @default.
• W4386780912 hasAuthorship W4386780912A5006372952 @default.
• W4386780912 hasAuthorship W4386780912A5011529063 @default.
• W4386780912 hasAuthorship W4386780912A5011736892 @default.
• W4386780912 hasAuthorship W4386780912A5011897595 @default.
• W4386780912 hasAuthorship W4386780912A5013929903 @default.
• W4386780912 hasAuthorship W4386780912A5014431719 @default.
• W4386780912 hasAuthorship W4386780912A5015365039 @default.
• W4386780912 hasAuthorship W4386780912A5015888636 @default.
• W4386780912 hasAuthorship W4386780912A5023728016 @default.
• W4386780912 hasAuthorship W4386780912A5034181399 @default.
• W4386780912 hasAuthorship W4386780912A5035746810 @default.
• W4386780912 hasAuthorship W4386780912A5038693643 @default.
• W4386780912 hasAuthorship W4386780912A5039057642 @default.
• W4386780912 hasAuthorship W4386780912A5042829932 @default.
• W4386780912 hasAuthorship W4386780912A5046772202 @default.
• W4386780912 hasAuthorship W4386780912A5047764826 @default.
• W4386780912 hasAuthorship W4386780912A5050368246 @default.
• W4386780912 hasAuthorship W4386780912A5055163444 @default.
• W4386780912 hasAuthorship W4386780912A5057941081 @default.
• W4386780912 hasAuthorship W4386780912A5060907157 @default.
• W4386780912 hasAuthorship W4386780912A5060982517 @default.
• W4386780912 hasAuthorship W4386780912A5065098368 @default.
• W4386780912 hasAuthorship W4386780912A5067297056 @default.
• W4386780912 hasAuthorship W4386780912A5069624084 @default.
• W4386780912 hasAuthorship W4386780912A5071257161 @default.
• W4386780912 hasAuthorship W4386780912A5072336042 @default.
• W4386780912 hasAuthorship W4386780912A5074844653 @default.
• W4386780912 hasAuthorship W4386780912A5077063317 @default.
• W4386780912 hasAuthorship W4386780912A5077103444 @default.
• W4386780912 hasAuthorship W4386780912A5079969736 @default.
• W4386780912 hasAuthorship W4386780912A5081650701 @default.
• W4386780912 hasAuthorship W4386780912A5087995871 @default.
• W4386780912 hasAuthorship W4386780912A5090009905 @default.
• W4386780912 hasConcept C126322002 @default.
• W4386780912 hasConcept C203014093 @default.
• W4386780912 hasConcept C2776112149 @default.
• W4386780912 hasConcept C2778690821 @default.
• W4386780912 hasConcept C2780007613 @default.
• W4386780912 hasConcept C2780076729 @default.
• W4386780912 hasConcept C2780559512 @default.
• W4386780912 hasConcept C2780931953 @default.
• W4386780912 hasConcept C71924100 @default.
• W4386780912 hasConcept C90924648 @default.
• W4386780912 hasConceptScore W4386780912C126322002 @default.
• W4386780912 hasConceptScore W4386780912C203014093 @default.
• W4386780912 hasConceptScore W4386780912C2776112149 @default.
• W4386780912 hasConceptScore W4386780912C2778690821 @default.
• W4386780912 hasConceptScore W4386780912C2780007613 @default.
• W4386780912 hasConceptScore W4386780912C2780076729 @default.
• W4386780912 hasConceptScore W4386780912C2780559512 @default.
• W4386780912 hasConceptScore W4386780912C2780931953 @default.
• W4386780912 hasConceptScore W4386780912C71924100 @default.
• W4386780912 hasConceptScore W4386780912C90924648 @default.
• W4386780912 hasLocation W43867809121 @default.
• W4386780912 hasOpenAccess W4386780912 @default.

• next