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- W4386782010 abstract "Achilles tendon (AT) injury is one of the most common tendon injuries, especially in athletes, the elderly, and working-age people. In AT injury, the biomechanical properties of the tendon are severely affected, leading to abnormal function. In recent years, many efforts have been underway to develop effective treatments for AT injuries to enable patients to return to sports faster. For instance, several new techniques for tissue-engineered biological augmentation for tendon healing, growth factors (GFs), gene therapy, and mesenchymal stem cells were introduced. Increasing evidence has suggested that GFs can reduce inflammation, promote extracellular matrix production, and accelerate AT repair. In this review, we highlighted some recent investigations regarding the role of GFs, such as transforming GF-β(TGF-β), bone morphogenetic proteins (BMP), fibroblast GF (FGF), vascular endothelial GF (VEGF), platelet-derived GF (PDGF), and insulin-like GF (IGF), in tendon healing. In addition, we summarized the clinical trials and animal experiments on the efficacy of GFs in AT repair. We also highlighted the advantages and disadvantages of the different isoforms of TGF-β and BMPs, including GFs combined with stem cells, scaffolds, or other GFs. The strategies discussed in this review are currently in the early stages of development. It is noteworthy that although these emerging technologies may potentially develop into substantial clinical treatment options for AT injury, definitive conclusions on the use of these techniques for routine management of tendon ailments could not be drawn due to the lack of data." @default.
- W4386782010 created "2023-09-16" @default.
- W4386782010 creator A5000432967 @default.
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- W4386782010 date "2023-09-14" @default.
- W4386782010 modified "2023-10-17" @default.
- W4386782010 title "Growth factors in the treatment of Achilles tendon injury" @default.
- W4386782010 cites W1519663140 @default.
- W4386782010 cites W1534277560 @default.
- W4386782010 cites W1537102419 @default.
- W4386782010 cites W1547353239 @default.
- W4386782010 cites W1568872372 @default.
- W4386782010 cites W1583571382 @default.
- W4386782010 cites W1688287305 @default.
- W4386782010 cites W1895210946 @default.
- W4386782010 cites W1909152361 @default.
- W4386782010 cites W1916501302 @default.
- W4386782010 cites W1919664829 @default.
- W4386782010 cites W1934940546 @default.
- W4386782010 cites W1964368920 @default.
- W4386782010 cites W1966743083 @default.
- W4386782010 cites W1970819764 @default.
- W4386782010 cites W1974701423 @default.
- W4386782010 cites W1976785953 @default.
- W4386782010 cites W1978859045 @default.
- W4386782010 cites W1980867086 @default.
- W4386782010 cites W1984071676 @default.
- W4386782010 cites W1989035148 @default.
- W4386782010 cites W1990098492 @default.
- W4386782010 cites W1991977814 @default.
- W4386782010 cites W1993064711 @default.
- W4386782010 cites W1994167173 @default.
- W4386782010 cites W1994768775 @default.
- W4386782010 cites W1997680500 @default.
- W4386782010 cites W1997782975 @default.
- W4386782010 cites W1999851686 @default.
- W4386782010 cites W2007251503 @default.
- W4386782010 cites W2013217421 @default.
- W4386782010 cites W2017458997 @default.
- W4386782010 cites W2018535224 @default.
- W4386782010 cites W2024049105 @default.
- W4386782010 cites W2027519024 @default.
- W4386782010 cites W2029002097 @default.
- W4386782010 cites W2031328702 @default.
- W4386782010 cites W2036722670 @default.
- W4386782010 cites W2037056435 @default.
- W4386782010 cites W2039781989 @default.
- W4386782010 cites W2041518387 @default.
- W4386782010 cites W2042014093 @default.
- W4386782010 cites W2043884900 @default.
- W4386782010 cites W2052082578 @default.
- W4386782010 cites W2052240524 @default.
- W4386782010 cites W2052370257 @default.
- W4386782010 cites W2053067495 @default.
- W4386782010 cites W2063616711 @default.
- W4386782010 cites W2064033214 @default.
- W4386782010 cites W2071824292 @default.
- W4386782010 cites W2075600589 @default.
- W4386782010 cites W2079539335 @default.
- W4386782010 cites W2082152761 @default.
- W4386782010 cites W2098822366 @default.
- W4386782010 cites W2101437484 @default.
- W4386782010 cites W2115697285 @default.
- W4386782010 cites W2117588639 @default.
- W4386782010 cites W2126582098 @default.
- W4386782010 cites W2127748623 @default.
- W4386782010 cites W2131480053 @default.
- W4386782010 cites W2132709849 @default.
- W4386782010 cites W2136332052 @default.
- W4386782010 cites W2137776337 @default.
- W4386782010 cites W2142266939 @default.
- W4386782010 cites W2147467536 @default.
- W4386782010 cites W2149179723 @default.
- W4386782010 cites W2152367550 @default.
- W4386782010 cites W2152500928 @default.
- W4386782010 cites W2158175963 @default.
- W4386782010 cites W2162700482 @default.
- W4386782010 cites W2165237388 @default.
- W4386782010 cites W2167552812 @default.
- W4386782010 cites W2183495679 @default.
- W4386782010 cites W2187282310 @default.
- W4386782010 cites W2271349749 @default.
- W4386782010 cites W2277455154 @default.
- W4386782010 cites W2296433789 @default.
- W4386782010 cites W2333953997 @default.
- W4386782010 cites W2335679153 @default.
- W4386782010 cites W2345432299 @default.
- W4386782010 cites W2394843754 @default.
- W4386782010 cites W2442244161 @default.
- W4386782010 cites W2477998519 @default.
- W4386782010 cites W2530526528 @default.
- W4386782010 cites W2550764143 @default.
- W4386782010 cites W2564552852 @default.