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- W4386783452 endingPage "e15977" @default.
- W4386783452 startingPage "e15977" @default.
- W4386783452 abstract "Alcohol-related liver disease (ALD) is chronic liver damage caused by long-term heavy drinking with, extremely complicated pathogenesis. The current studies speculated that excessive alcohol and its metabolites are the major causes of liver cell toxicity. Autophagy is evolutionarily conserved in eukaryotes and aggravates alcoholic liver damage, through various mechanisms, such as cellular oxidative stress, inflammation, mitochondrial damage and lipid metabolism disorders. Therefore, autophagy plays an critical role in the occurrence and development of ALD. Some studies have shown that traditional Chinese medicine extracts improve the histological characteristics of ALD, as reflected in the improvement of oxidative stress and lipid droplet clearance, which might be achieved by inducing autophagy. This article reviews the mechanisms of quercetin, baicalin, glycycoumarin, salvianolic acid A, resveratrol, ginsenoside rg1, and dihydromyricetin inducing autophagy and their participation in the inhibition of ALD. The regulation of autophagy in ALD by these traditional Chinese medicine extracts provides novel ideas for the treatment of the disease; however, its molecular mechanism needs to be elucidated further." @default.
- W4386783452 created "2023-09-16" @default.
- W4386783452 creator A5025854267 @default.
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- W4386783452 creator A5074220692 @default.
- W4386783452 creator A5086281345 @default.
- W4386783452 creator A5091624258 @default.
- W4386783452 date "2023-09-15" @default.
- W4386783452 modified "2023-09-27" @default.
- W4386783452 title "Progress in the mechanism of autophagy and traditional Chinese medicine herb involved in alcohol-related liver disease" @default.
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