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- W4386783969 abstract "This chapter looks at the various issues that need to be tackled before a promising-looking drug candidate reaches the clinic and goes into full-scale production. It discusses toxicity tests that are carried out <italic>in vitro</italic> and <italic>in vivo</italic> on drug candidates to assess acute and chronic toxicity. It also examines drug metabolism studies which are carried out on animals and humans to identify drug metabolites, noting how a drug candidate is labelled with an isotope to aid the detection of metabolites. The chapter explores pharmacology tests whcih are carried out to determine a drug's mechanism of action and to determine whether it acts at targets other than the intended ones. The chapter reviews formulation studies that aim to develop a preparation of the drug that can be administered during clinical trials and beyond." @default.
- W4386783969 created "2023-09-16" @default.
- W4386783969 creator A5041255871 @default.
- W4386783969 date "2023-03-16" @default.
- W4386783969 modified "2023-09-26" @default.
- W4386783969 title "Getting the drug to market" @default.
- W4386783969 doi "https://doi.org/10.1093/hesc/9780198866664.003.00019" @default.
- W4386783969 hasPublicationYear "2023" @default.
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