FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386784368> ?p ?o ?g. }

• W4386784368 abstract "Achieving and maintaining a low-risk profile is associated with favorable outcome in pulmonary arterial hypertension (PAH). The effects of treatment on risk profile are variable among patients.To Identify variables that might predict the response to treatment with phosphodiesterase-5 inhibitors (PDE-5i) in PAH.We carried out a cohort analysis of the Spanish PAH registry in 830 patients diagnosed with PAH that started PDE5i treatment and had > 1 year follow-up. 644 patients started PDE-5i either in mono- or add-on therapy and 186 started combined treatment with PDE-5i and endothelin receptor antagonist (ERA). Responders were considered when at 1 year they: (1) were alive; (2) did not present clinical worsening; and (3) improved European Society of Cardiology/European Respiratory Society (ESC/ERS) risk score or remained in low-risk. Univariate and multivariate logistic regression models were used to analyze variables associated with a favorable response.Two hundred and ten patients (33%) starting PDE-5i alone were classified as responders, irrespective of whether it was mono- or add-on therapy. In addition to known predictors of PAH outcome (low-risk at baseline, younger age), male sex and diagnosis of portopulmonary hypertension (PoPH) or HIV-PAH were independent predictors of favorable response to PDE-5i. Diffusing capacity for carbon monoxide (DLco) ≤ 40% of predicted was associated with an unfavorable response. When PDE-5i were used in upfront combination, 58% of patients were responders. In this group, diagnosis of idiopathic PAH (IPAH) was an independent predictor of favorable response, whereas connective tissue disease-PAH was associated with an unfavorable response.Male sex and diagnosis of PoPH or HIV-PAH are predictors of favorable effect of PDE-5i on risk profile when used as mono- or add-on therapy. Patients with IPAH respond more favorably to PDE-5i when used in upfront combination. These results identify patient profiles that may respond favorably to PDE-5i in monotherapy and those who might benefit from alternative treatment strategies." @default.
• W4386784368 created "2023-09-16" @default.
• W4386784368 creator A5002417355 @default.
• W4386784368 creator A5006326195 @default.
• W4386784368 creator A5012223419 @default.
• W4386784368 creator A5012598462 @default.
• W4386784368 creator A5024868105 @default.
• W4386784368 creator A5029685260 @default.
• W4386784368 creator A5050570619 @default.
• W4386784368 creator A5058491603 @default.
• W4386784368 creator A5065128952 @default.
• W4386784368 creator A5092880828 @default.
• W4386784368 date "2023-09-15" @default.
• W4386784368 modified "2023-10-15" @default.
• W4386784368 title "Predictors of the response to phosphodiesterase-5 inhibitors in pulmonary arterial hypertension: an analysis of the Spanish registry" @default.
• W4386784368 cites W1480678630 @default.
• W4386784368 cites W1995110919 @default.
• W4386784368 cites W2000494514 @default.
• W4386784368 cites W2009879610 @default.
• W4386784368 cites W2019985521 @default.
• W4386784368 cites W2024102156 @default.
• W4386784368 cites W2035736227 @default.
• W4386784368 cites W2047189953 @default.
• W4386784368 cites W2052035277 @default.
• W4386784368 cites W2069727305 @default.
• W4386784368 cites W2086107772 @default.
• W4386784368 cites W2093354189 @default.
• W4386784368 cites W2106199142 @default.
• W4386784368 cites W2112229901 @default.
• W4386784368 cites W2134612237 @default.
• W4386784368 cites W2140319297 @default.
• W4386784368 cites W2148797779 @default.
• W4386784368 cites W2150049345 @default.
• W4386784368 cites W2151863430 @default.
• W4386784368 cites W2156214513 @default.
• W4386784368 cites W2158478351 @default.
• W4386784368 cites W2165696637 @default.
• W4386784368 cites W2621229357 @default.
• W4386784368 cites W2744074505 @default.
• W4386784368 cites W280493037 @default.
• W4386784368 cites W2891294583 @default.
• W4386784368 cites W2904385559 @default.
• W4386784368 cites W2948867885 @default.
• W4386784368 cites W2989138579 @default.
• W4386784368 cites W2999337680 @default.
• W4386784368 cites W3002320843 @default.
• W4386784368 cites W3010286720 @default.
• W4386784368 cites W3026404824 @default.
• W4386784368 cites W3032520768 @default.
• W4386784368 cites W3082039301 @default.
• W4386784368 cites W3090725879 @default.
• W4386784368 cites W3098577915 @default.
• W4386784368 cites W3138574248 @default.
• W4386784368 cites W3174814045 @default.
• W4386784368 cites W3206212741 @default.
• W4386784368 cites W3209216959 @default.
• W4386784368 cites W4210753629 @default.
• W4386784368 cites W4213271797 @default.
• W4386784368 cites W4285404810 @default.
• W4386784368 cites W4288430356 @default.
• W4386784368 cites W4293207258 @default.
• W4386784368 doi "https://doi.org/10.1186/s12931-023-02531-1" @default.
• W4386784368 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37715261" @default.
• W4386784368 hasPublicationYear "2023" @default.
• W4386784368 type Work @default.
• W4386784368 citedByCount "0" @default.
• W4386784368 crossrefType "journal-article" @default.
• W4386784368 hasAuthorship W4386784368A5002417355 @default.
• W4386784368 hasAuthorship W4386784368A5006326195 @default.
• W4386784368 hasAuthorship W4386784368A5012223419 @default.
• W4386784368 hasAuthorship W4386784368A5012598462 @default.
• W4386784368 hasAuthorship W4386784368A5024868105 @default.
• W4386784368 hasAuthorship W4386784368A5029685260 @default.
• W4386784368 hasAuthorship W4386784368A5050570619 @default.
• W4386784368 hasAuthorship W4386784368A5058491603 @default.
• W4386784368 hasAuthorship W4386784368A5065128952 @default.
• W4386784368 hasAuthorship W4386784368A5092880828 @default.
• W4386784368 hasBestOaLocation W43867843681 @default.
• W4386784368 hasConcept C126322002 @default.
• W4386784368 hasConcept C144301174 @default.
• W4386784368 hasConcept C144980905 @default.
• W4386784368 hasConcept C151956035 @default.
• W4386784368 hasConcept C16020263 @default.
• W4386784368 hasConcept C164705383 @default.
• W4386784368 hasConcept C165637977 @default.
• W4386784368 hasConcept C170493617 @default.
• W4386784368 hasConcept C2776345702 @default.
• W4386784368 hasConcept C2777714996 @default.
• W4386784368 hasConcept C2780930700 @default.
• W4386784368 hasConcept C3018587741 @default.
• W4386784368 hasConcept C38180746 @default.
• W4386784368 hasConcept C71924100 @default.
• W4386784368 hasConcept C72563966 @default.
• W4386784368 hasConceptScore W4386784368C126322002 @default.
• W4386784368 hasConceptScore W4386784368C144301174 @default.
• W4386784368 hasConceptScore W4386784368C144980905 @default.
• W4386784368 hasConceptScore W4386784368C151956035 @default.
• W4386784368 hasConceptScore W4386784368C16020263 @default.
• W4386784368 hasConceptScore W4386784368C164705383 @default.
• W4386784368 hasConceptScore W4386784368C165637977 @default.

• next