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- W4386784679 endingPage "14110" @default.
- W4386784679 startingPage "14110" @default.
- W4386784679 abstract "Non-Hodgkin lymphoma's (NHL) incidence is rising over time, and B cell lymphomas comprise the majority of lymphomas. The phosphoinositide 3-kinase (PI3K)/v-akt murine thymoma viral oncogene homologue 1 (Akt)/mammalian target of the rapamycin (mTOR) signaling pathway plays a critical role in a variety of cellular processes, such as cell proliferation and survival. Its role in lymphomagenesis is confirmed in many different types of B cell lymphomas. This review is mainly focused on the PI3K/v-akt/mTOR pathway-related oncogenic mechanisms in B cell NHLs with an emphasis on common B cell lymphoma types [diffuse large B cell lymphoma (DLBCL) and mantle cell lymphoma (MCL)]. Furthermore, it summarizes the literature regarding the clinical applications of the mTOR inhibitors temsirolimus and everolimus in B cell NHLs, which have been tested in a range of clinical trials enrolling patients with B cell malignancies, either as monotherapy or in combination with other agents or regimens." @default.
- W4386784679 created "2023-09-16" @default.
- W4386784679 creator A5001887761 @default.
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- W4386784679 creator A5042377554 @default.
- W4386784679 creator A5052426158 @default.
- W4386784679 creator A5087124177 @default.
- W4386784679 date "2023-09-14" @default.
- W4386784679 modified "2023-10-17" @default.
- W4386784679 title "The Role of mTOR in B Cell Lymphoid Malignancies: Biologic and Therapeutic Aspects" @default.
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