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• W4386785551 abstract "We report the successful evaluation of a US Pharmacopeia Apparatus 4 (USP-4) system in measuring the dissolution profiles of man-made vitreous fibers (MMVF)1. Glass and stone wool fibers with different (high- and low-) solubility profiles were tested in closed-loop configuration using a sodium/potassium phosphate buffer solution or an acetate buffer, respectively. Results confirm a need to operate in diluted conditions to avoid silicon saturation in the simulant solution and suppression of fiber dissolution. A clear fiber-to-fiber differentiation with good cell-to-cell reproducibility was achieved. These findings support the continued development of a USP-4 protocol for MMVF in vitro acellular testing." @default.
• W4386785551 created "2023-09-16" @default.
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• W4386785551 date "2023-09-01" @default.
• W4386785551 modified "2023-10-11" @default.
• W4386785551 title "Initial Evaluation of USP Apparatus 4 for Measuring Dissolution Profile of Man-Made Vitreous Fibers" @default.
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• W4386785551 doi "https://doi.org/10.1016/j.toxlet.2023.09.005" @default.
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