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• W4386793946 endingPage "101790" @default.
• W4386793946 startingPage "101790" @default.
• W4386793946 abstract "Cancer cells often depend on multiple pathways for their growth and survival, resulting in therapeutic resistance and the limited effectiveness of treatments. Combination therapy has emerged as a favorable approach to enhance treatment efficacy and minimize acquired resistance and harmful side effects. The murine double minute 2 (MDM2) protein regulates cellular proliferation and promotes cancer-related activities by negatively regulating the tumor suppressor protein p53. MDM2 aberrations have been reported in a variety of human cancers, making it an appealing target for cancer therapy. As a result, several small-molecule MDM2 inhibitors have been developed and are currently being investigated in clinical studies. Nevertheless, it has been shown that the inhibition of MDM2 alone is inadequate to achieve long-term suppression of tumor growth, thus prompting the need for further investigation into combination therapeutic strategies. In this review, possible clinical and preclinical MDM2 combination inhibitor regimens are thoroughly analyzed and discussed. It provides a rationale for combining MDM2 inhibitors with other therapeutic approaches in the management of cancer, taking into consideration ongoing clinical trials that evaluate the combination of MDM2 inhibitors. The review explores the current status of MDM2 inhibitors in combination with chemotherapy or targeted therapy, as well as promising approach of combining MDM2 inhibitors with immunotherapy. In addition, it investigates the function of PROTACs as MDM2 degraders in cancer treatment. A comprehensive examination of these combination regimens highlights the potential for advancing MDM2-inhibitor therapy and improving clinical outcomes for cancer patients and establishes the foundation for future research and development in this promising area of study." @default.
• W4386793946 created "2023-09-16" @default.
• W4386793946 creator A5001330294 @default.
• W4386793946 date "2023-10-01" @default.
• W4386793946 modified "2023-10-13" @default.
• W4386793946 title "Advancements in MDM2 Inhibition: Clinical and Pre-clinical Investigations of Combination Therapeutic Regimens" @default.
• W4386793946 cites W143775612 @default.
• W4386793946 cites W1554671812 @default.
• W4386793946 cites W1576330810 @default.
• W4386793946 cites W1591281137 @default.
• W4386793946 cites W1592021885 @default.
• W4386793946 cites W1763522509 @default.
• W4386793946 cites W1822460389 @default.
• W4386793946 cites W1895234166 @default.
• W4386793946 cites W1964389487 @default.
• W4386793946 cites W1965173366 @default.
• W4386793946 cites W1966163762 @default.
• W4386793946 cites W1976295398 @default.
• W4386793946 cites W1983610544 @default.
• W4386793946 cites W1990054550 @default.
• W4386793946 cites W1991167758 @default.
• W4386793946 cites W1991451193 @default.
• W4386793946 cites W1993293652 @default.
• W4386793946 cites W1993964347 @default.
• W4386793946 cites W1994852323 @default.
• W4386793946 cites W1996523330 @default.
• W4386793946 cites W1996632098 @default.
• W4386793946 cites W2003463790 @default.
• W4386793946 cites W2004311983 @default.
• W4386793946 cites W2004550238 @default.
• W4386793946 cites W2005438382 @default.
• W4386793946 cites W2006176372 @default.
• W4386793946 cites W2007249806 @default.
• W4386793946 cites W2018478612 @default.
• W4386793946 cites W2023950025 @default.
• W4386793946 cites W2034177818 @default.
• W4386793946 cites W2047590682 @default.
• W4386793946 cites W2054322190 @default.
• W4386793946 cites W2059407064 @default.
• W4386793946 cites W2061168609 @default.
• W4386793946 cites W2061821733 @default.
• W4386793946 cites W2073936529 @default.
• W4386793946 cites W2074546881 @default.
• W4386793946 cites W2075889618 @default.
• W4386793946 cites W2081953771 @default.
• W4386793946 cites W2082979850 @default.
• W4386793946 cites W2088371348 @default.
• W4386793946 cites W2095014345 @default.
• W4386793946 cites W2097933346 @default.
• W4386793946 cites W2099907467 @default.
• W4386793946 cites W2100494757 @default.
• W4386793946 cites W2102498455 @default.
• W4386793946 cites W2104608023 @default.
• W4386793946 cites W2105602271 @default.
• W4386793946 cites W2106048601 @default.
• W4386793946 cites W2107418471 @default.
• W4386793946 cites W2113588690 @default.
• W4386793946 cites W2115509961 @default.
• W4386793946 cites W2118129019 @default.
• W4386793946 cites W2124433932 @default.
• W4386793946 cites W2126316295 @default.
• W4386793946 cites W2130766483 @default.
• W4386793946 cites W2135300227 @default.
• W4386793946 cites W2146207872 @default.
• W4386793946 cites W2155906069 @default.
• W4386793946 cites W2160178368 @default.
• W4386793946 cites W2175728132 @default.
• W4386793946 cites W2182708897 @default.
• W4386793946 cites W2219581260 @default.
• W4386793946 cites W2272978256 @default.
• W4386793946 cites W2298292815 @default.
• W4386793946 cites W2303171964 @default.
• W4386793946 cites W2428075992 @default.
• W4386793946 cites W2475371777 @default.
• W4386793946 cites W2515257886 @default.
• W4386793946 cites W2522030015 @default.
• W4386793946 cites W2527179423 @default.
• W4386793946 cites W2530659680 @default.
• W4386793946 cites W2586389371 @default.
• W4386793946 cites W2593361213 @default.
• W4386793946 cites W2594386026 @default.
• W4386793946 cites W2594529508 @default.
• W4386793946 cites W2596468903 @default.
• W4386793946 cites W2607016203 @default.
• W4386793946 cites W2679430764 @default.
• W4386793946 cites W2729108853 @default.
• W4386793946 cites W2744254482 @default.
• W4386793946 cites W2770332728 @default.
• W4386793946 cites W2773114573 @default.
• W4386793946 cites W2776808515 @default.
• W4386793946 cites W2793399311 @default.
• W4386793946 cites W2808704696 @default.
• W4386793946 cites W2883445384 @default.
• W4386793946 cites W2888012200 @default.
• W4386793946 cites W2890084166 @default.
• W4386793946 cites W2895467863 @default.
• W4386793946 cites W2904458560 @default.
• W4386793946 cites W2905292440 @default.

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