Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386793956> ?p ?o ?g. }
- W4386793956 endingPage "107956" @default.
- W4386793956 startingPage "107956" @default.
- W4386793956 abstract "Pancreatic beta cells produce and secrete insulin as a response to rises in blood glucose. Despite the advances in understanding glucose-regulated insulin transcription and translation the mechanisms triggering the synthesis of new insulin molecules are still incompletely described. In this report, we identify EDEM1 as a new modulator of insulin synthesis and secretion. In the presence of EDEM1, INS-1E cells secrete significantly more insulin upon glucose stimulation compared to control cells. We found that overexpression of EDEM1 inhibited the IRE1/JNK/c-Jun pathway, leading to an increase in the insulin mRNA level. Similarly, EDEM1 transduced human islets secreted significantly more insulin upon stimulation. Furthermore, EDEM1 improved insulin secretion restoring normoglycemia and glucose tolerance in diabetic rats. We propose EDEM1 as a regulator of the UPR via IRE1/XBP1s and IRE1/JNK/c-Jun signaling cascades and insulin transcription in pancreatic β-cells, supporting EDEM1 as a potential target for the treatment of diabetes." @default.
- W4386793956 created "2023-09-16" @default.
- W4386793956 creator A5014772121 @default.
- W4386793956 creator A5023084694 @default.
- W4386793956 creator A5025897556 @default.
- W4386793956 creator A5077249043 @default.
- W4386793956 creator A5081005463 @default.
- W4386793956 creator A5092885656 @default.
- W4386793956 date "2023-10-01" @default.
- W4386793956 modified "2023-10-18" @default.
- W4386793956 title "EDEM1 regulates the insulin mRNA level by inhibiting the ER stress-induced IRE1/JNK/c-Jun pathway" @default.
- W4386793956 cites W135283770 @default.
- W4386793956 cites W1481795283 @default.
- W4386793956 cites W1964706050 @default.
- W4386793956 cites W1966428323 @default.
- W4386793956 cites W1970090817 @default.
- W4386793956 cites W1973295477 @default.
- W4386793956 cites W1974558745 @default.
- W4386793956 cites W1981551685 @default.
- W4386793956 cites W1984672567 @default.
- W4386793956 cites W1993697882 @default.
- W4386793956 cites W1995699883 @default.
- W4386793956 cites W2023397454 @default.
- W4386793956 cites W2027536811 @default.
- W4386793956 cites W2043681654 @default.
- W4386793956 cites W2049270390 @default.
- W4386793956 cites W2063042519 @default.
- W4386793956 cites W2079986746 @default.
- W4386793956 cites W2080901528 @default.
- W4386793956 cites W2088012387 @default.
- W4386793956 cites W2109444195 @default.
- W4386793956 cites W2111192178 @default.
- W4386793956 cites W2112881051 @default.
- W4386793956 cites W2115205812 @default.
- W4386793956 cites W2119304571 @default.
- W4386793956 cites W2122333565 @default.
- W4386793956 cites W2145869245 @default.
- W4386793956 cites W2154784486 @default.
- W4386793956 cites W2156602181 @default.
- W4386793956 cites W2159586070 @default.
- W4386793956 cites W2171435018 @default.
- W4386793956 cites W2174130773 @default.
- W4386793956 cites W2192080449 @default.
- W4386793956 cites W2339438128 @default.
- W4386793956 cites W2602883699 @default.
- W4386793956 cites W2789501995 @default.
- W4386793956 cites W2883231068 @default.
- W4386793956 cites W2947719831 @default.
- W4386793956 cites W2983567059 @default.
- W4386793956 cites W3011302422 @default.
- W4386793956 cites W3158921277 @default.
- W4386793956 cites W3158933345 @default.
- W4386793956 cites W3204045656 @default.
- W4386793956 cites W4292266469 @default.
- W4386793956 doi "https://doi.org/10.1016/j.isci.2023.107956" @default.
- W4386793956 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37822496" @default.
- W4386793956 hasPublicationYear "2023" @default.
- W4386793956 type Work @default.
- W4386793956 citedByCount "0" @default.
- W4386793956 crossrefType "journal-article" @default.
- W4386793956 hasAuthorship W4386793956A5014772121 @default.
- W4386793956 hasAuthorship W4386793956A5023084694 @default.
- W4386793956 hasAuthorship W4386793956A5025897556 @default.
- W4386793956 hasAuthorship W4386793956A5077249043 @default.
- W4386793956 hasAuthorship W4386793956A5081005463 @default.
- W4386793956 hasAuthorship W4386793956A5092885656 @default.
- W4386793956 hasBestOaLocation W43867939561 @default.
- W4386793956 hasConcept C104317684 @default.
- W4386793956 hasConcept C126322002 @default.
- W4386793956 hasConcept C134018914 @default.
- W4386793956 hasConcept C138885662 @default.
- W4386793956 hasConcept C165220095 @default.
- W4386793956 hasConcept C179926584 @default.
- W4386793956 hasConcept C185592680 @default.
- W4386793956 hasConcept C24998067 @default.
- W4386793956 hasConcept C2776828364 @default.
- W4386793956 hasConcept C2779087070 @default.
- W4386793956 hasConcept C2779306644 @default.
- W4386793956 hasConcept C2779855799 @default.
- W4386793956 hasConcept C41895202 @default.
- W4386793956 hasConcept C49039625 @default.
- W4386793956 hasConcept C55493867 @default.
- W4386793956 hasConcept C71924100 @default.
- W4386793956 hasConcept C86339819 @default.
- W4386793956 hasConcept C86803240 @default.
- W4386793956 hasConcept C95444343 @default.
- W4386793956 hasConceptScore W4386793956C104317684 @default.
- W4386793956 hasConceptScore W4386793956C126322002 @default.
- W4386793956 hasConceptScore W4386793956C134018914 @default.
- W4386793956 hasConceptScore W4386793956C138885662 @default.
- W4386793956 hasConceptScore W4386793956C165220095 @default.
- W4386793956 hasConceptScore W4386793956C179926584 @default.
- W4386793956 hasConceptScore W4386793956C185592680 @default.
- W4386793956 hasConceptScore W4386793956C24998067 @default.
- W4386793956 hasConceptScore W4386793956C2776828364 @default.
- W4386793956 hasConceptScore W4386793956C2779087070 @default.
- W4386793956 hasConceptScore W4386793956C2779306644 @default.
- W4386793956 hasConceptScore W4386793956C2779855799 @default.