Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386793971> ?p ?o ?g. }
- W4386793971 endingPage "146092" @default.
- W4386793971 startingPage "146092" @default.
- W4386793971 abstract "Diabetic wound care continues a significant clinical problem due to the complex wound microenvironment characterized by excessive ROS, bacterial infection, persistent inflammation, impaired NAD+ biosynthesis, and angiopathy. Particularly, scavenging ROS, enhancing NAD+ levels and promoting angiogenesis are critical for improving diabetic wound healing. This study presents a novel in situ injectable hydrogel based on poly(glycerol sebacate)–co-poly(ethylene glycol)-g-catechol prepolymer (PEGSD) and quaternized chitosan (QCS), which is further loaded with nicotinamide mononucleotide (NMN) and Mg2+ (QP/NMN/Mg2+) and catalytically cross-linked by a mild horseradish peroxidase (HRP)/H2O2 system for type II diabetic wound healing. The hydrogel shows multifunctional properties including excellent biocompatibility, tissue adhesion, rapid hemostasis, antibacterial activity, ROS scavenging and angiogenesis promotion. The coordination and electrostatic interactions ensure the prolonged release of NMN and Mg2+. Specifically, as an NAD+ precursor, the addition of NMN further alleviates oxidative stress and rescues angiogenic capacity. Moreover, the presence of Mg2+ enhances the antibacterial activity of hydrogel against S. aureus. The results demonstrate the synergy of NMN and Mg2+ in hydrogel significantly promotes HUVEC proliferation tube formation, fibroblast migration, and greatly accelerates diabetic wound healing, presenting a feasible strategy for chronic diabetic wound repair." @default.
- W4386793971 created "2023-09-16" @default.
- W4386793971 creator A5013258207 @default.
- W4386793971 creator A5023992952 @default.
- W4386793971 creator A5036843958 @default.
- W4386793971 creator A5049729588 @default.
- W4386793971 creator A5055384318 @default.
- W4386793971 creator A5066599847 @default.
- W4386793971 creator A5077940282 @default.
- W4386793971 creator A5085577563 @default.
- W4386793971 creator A5088888459 @default.
- W4386793971 creator A5091612515 @default.
- W4386793971 date "2023-11-01" @default.
- W4386793971 modified "2023-10-03" @default.
- W4386793971 title "Injectable, antibacterial, ROS scavenging and pro-angiogenic hydrogel adhesives promote chronic wound healing in diabetes via synergistic release of NMN and Mg2+" @default.
- W4386793971 cites W1161655524 @default.
- W4386793971 cites W1766761376 @default.
- W4386793971 cites W1967098964 @default.
- W4386793971 cites W1968044382 @default.
- W4386793971 cites W1980220254 @default.
- W4386793971 cites W2009315749 @default.
- W4386793971 cites W2024159944 @default.
- W4386793971 cites W2035332297 @default.
- W4386793971 cites W2038011036 @default.
- W4386793971 cites W2039093900 @default.
- W4386793971 cites W2065577291 @default.
- W4386793971 cites W2065803399 @default.
- W4386793971 cites W2092858957 @default.
- W4386793971 cites W2093168067 @default.
- W4386793971 cites W2109483577 @default.
- W4386793971 cites W2120472250 @default.
- W4386793971 cites W2156107131 @default.
- W4386793971 cites W2203744266 @default.
- W4386793971 cites W2299465542 @default.
- W4386793971 cites W2337349090 @default.
- W4386793971 cites W2521459783 @default.
- W4386793971 cites W2546015443 @default.
- W4386793971 cites W2579302807 @default.
- W4386793971 cites W2612072527 @default.
- W4386793971 cites W2775008495 @default.
- W4386793971 cites W2791288341 @default.
- W4386793971 cites W2802760127 @default.
- W4386793971 cites W2808115170 @default.
- W4386793971 cites W2857318559 @default.
- W4386793971 cites W2888118846 @default.
- W4386793971 cites W2889383095 @default.
- W4386793971 cites W2900540898 @default.
- W4386793971 cites W2903169176 @default.
- W4386793971 cites W2904564895 @default.
- W4386793971 cites W2910427235 @default.
- W4386793971 cites W2916903224 @default.
- W4386793971 cites W2918042433 @default.
- W4386793971 cites W2932633795 @default.
- W4386793971 cites W2944564829 @default.
- W4386793971 cites W2950151274 @default.
- W4386793971 cites W2962693889 @default.
- W4386793971 cites W2971543200 @default.
- W4386793971 cites W2988661975 @default.
- W4386793971 cites W2996682146 @default.
- W4386793971 cites W3006819626 @default.
- W4386793971 cites W3007087975 @default.
- W4386793971 cites W3007205390 @default.
- W4386793971 cites W3010589531 @default.
- W4386793971 cites W3012343336 @default.
- W4386793971 cites W3014999217 @default.
- W4386793971 cites W3021164543 @default.
- W4386793971 cites W3024663407 @default.
- W4386793971 cites W3042869760 @default.
- W4386793971 cites W3048490678 @default.
- W4386793971 cites W3048910908 @default.
- W4386793971 cites W3091984293 @default.
- W4386793971 cites W3102558410 @default.
- W4386793971 cites W3103615401 @default.
- W4386793971 cites W3104289109 @default.
- W4386793971 cites W3109510179 @default.
- W4386793971 cites W3115773653 @default.
- W4386793971 cites W3116757665 @default.
- W4386793971 cites W3128903402 @default.
- W4386793971 cites W3133905451 @default.
- W4386793971 cites W3139239834 @default.
- W4386793971 cites W3148272723 @default.
- W4386793971 cites W3153335336 @default.
- W4386793971 cites W3156374487 @default.
- W4386793971 cites W3164079031 @default.
- W4386793971 cites W3183187970 @default.
- W4386793971 cites W3189826619 @default.
- W4386793971 cites W3191015620 @default.
- W4386793971 cites W3193219480 @default.
- W4386793971 cites W3203050421 @default.
- W4386793971 cites W4200110825 @default.
- W4386793971 cites W4200340709 @default.
- W4386793971 cites W4200352179 @default.
- W4386793971 cites W4206779940 @default.
- W4386793971 cites W4210568695 @default.
- W4386793971 cites W4220813423 @default.
- W4386793971 cites W4224440853 @default.
- W4386793971 cites W4306180892 @default.
- W4386793971 cites W4308156319 @default.