FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386796739> ?p ?o ?g. }

• W4386796739 endingPage "110960" @default.
• W4386796739 startingPage "110960" @default.
• W4386796739 abstract "Helicobacter pylori (H. pylori) infection is a common bacterial infection that is widespread globally. It is crucial to comprehend the molecular mechanisms that underlie the infection caused by H. pylori in order to devise successful therapeutic approaches. The objective of this study was to examine the involvement of Lipocalin-2 (LCN2) in the development of H. pylori infection. LCN2 expression levels in human gastric mucosa and H. pylori-infected mouse models were analyzed using quantitative PCR and immunohistochemistry methods. The effects of LCN2 on the attachment of H. pylori to gastric mucosa cells were assessed using bacterial culture and fluorescence intensity tests. To investigate the correlation between LCN2, CCL20, and IL-17A, we performed gene expression analysis and measured serum levels. The findings indicated an increase in LCN2 levels in the gastric mucosa of both patients and mice infected with H. pylori. Blocking the natural LCN2 resulted in an increased attachment of H. pylori to cells in the gastric mucosa. In addition, we noticed that reduced levels of LCN2 promoted the attachment of H. pylori to cells in the gastric mucosa. Furthermore, H. pylori-infected patients exhibited increased expression of both LCN2 and CCL20, and there was a positive correlation between serum levels of CCL20 and LCN2. LCN2 expression was found to depend on the presence of IL-17A, and inhibiting IL-17A led to a higher H. pylori colonization. The persistence of H. pylori infection is facilitated by the presence of low levels of LCN2, which is dependent on IL-17A. This finding offers valuable perspectives for the development of novel therapeutic approaches for H. pylori infection." @default.
• W4386796739 created "2023-09-17" @default.
• W4386796739 creator A5037109362 @default.
• W4386796739 creator A5073405503 @default.
• W4386796739 creator A5076359094 @default.
• W4386796739 creator A5084080614 @default.
• W4386796739 creator A5086058590 @default.
• W4386796739 date "2023-11-01" @default.
• W4386796739 modified "2023-10-18" @default.
• W4386796739 title "The contribution of IL-17A-dependent low LCN2 levels to Helicobacter pylori infection: Insights from clinical and experimental studies" @default.
• W4386796739 cites W1618624376 @default.
• W4386796739 cites W1902241237 @default.
• W4386796739 cites W1962077068 @default.
• W4386796739 cites W2000707384 @default.
• W4386796739 cites W2009307785 @default.
• W4386796739 cites W2014262351 @default.
• W4386796739 cites W2049476333 @default.
• W4386796739 cites W2074708346 @default.
• W4386796739 cites W2095100073 @default.
• W4386796739 cites W2099623158 @default.
• W4386796739 cites W2102266054 @default.
• W4386796739 cites W2105501814 @default.
• W4386796739 cites W2116719366 @default.
• W4386796739 cites W2125617732 @default.
• W4386796739 cites W2135407925 @default.
• W4386796739 cites W2143894870 @default.
• W4386796739 cites W2148920499 @default.
• W4386796739 cites W2171398182 @default.
• W4386796739 cites W2256719057 @default.
• W4386796739 cites W2527347986 @default.
• W4386796739 cites W2921655274 @default.
• W4386796739 cites W2924081358 @default.
• W4386796739 cites W2940545255 @default.
• W4386796739 cites W2997996943 @default.
• W4386796739 cites W3112802955 @default.
• W4386796739 cites W3144201774 @default.
• W4386796739 cites W3159570784 @default.
• W4386796739 cites W3159967417 @default.
• W4386796739 cites W3163502621 @default.
• W4386796739 cites W3175335269 @default.
• W4386796739 cites W3196742639 @default.
• W4386796739 cites W4210671390 @default.
• W4386796739 cites W4288696792 @default.
• W4386796739 cites W4294391344 @default.
• W4386796739 cites W4311230336 @default.
• W4386796739 cites W4323665364 @default.
• W4386796739 cites W4372329833 @default.
• W4386796739 doi "https://doi.org/10.1016/j.intimp.2023.110960" @default.
• W4386796739 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37722259" @default.
• W4386796739 hasPublicationYear "2023" @default.
• W4386796739 type Work @default.
• W4386796739 citedByCount "0" @default.
• W4386796739 crossrefType "journal-article" @default.
• W4386796739 hasAuthorship W4386796739A5037109362 @default.
• W4386796739 hasAuthorship W4386796739A5073405503 @default.
• W4386796739 hasAuthorship W4386796739A5076359094 @default.
• W4386796739 hasAuthorship W4386796739A5084080614 @default.
• W4386796739 hasAuthorship W4386796739A5086058590 @default.
• W4386796739 hasConcept C12823836 @default.
• W4386796739 hasConcept C13373296 @default.
• W4386796739 hasConcept C203014093 @default.
• W4386796739 hasConcept C2776409635 @default.
• W4386796739 hasConcept C2779422922 @default.
• W4386796739 hasConcept C2780832600 @default.
• W4386796739 hasConcept C2781443798 @default.
• W4386796739 hasConcept C54355233 @default.
• W4386796739 hasConcept C55493867 @default.
• W4386796739 hasConcept C83360876 @default.
• W4386796739 hasConcept C86803240 @default.
• W4386796739 hasConcept C8891405 @default.
• W4386796739 hasConceptScore W4386796739C12823836 @default.
• W4386796739 hasConceptScore W4386796739C13373296 @default.
• W4386796739 hasConceptScore W4386796739C203014093 @default.
• W4386796739 hasConceptScore W4386796739C2776409635 @default.
• W4386796739 hasConceptScore W4386796739C2779422922 @default.
• W4386796739 hasConceptScore W4386796739C2780832600 @default.
• W4386796739 hasConceptScore W4386796739C2781443798 @default.
• W4386796739 hasConceptScore W4386796739C54355233 @default.
• W4386796739 hasConceptScore W4386796739C55493867 @default.
• W4386796739 hasConceptScore W4386796739C83360876 @default.
• W4386796739 hasConceptScore W4386796739C86803240 @default.
• W4386796739 hasConceptScore W4386796739C8891405 @default.
• W4386796739 hasLocation W43867967391 @default.
• W4386796739 hasLocation W43867967392 @default.
• W4386796739 hasOpenAccess W4386796739 @default.
• W4386796739 hasPrimaryLocation W43867967391 @default.
• W4386796739 hasRelatedWork W1985883684 @default.
• W4386796739 hasRelatedWork W2030306745 @default.
• W4386796739 hasRelatedWork W2077202231 @default.
• W4386796739 hasRelatedWork W2130030508 @default.
• W4386796739 hasRelatedWork W2320798382 @default.
• W4386796739 hasRelatedWork W2393990627 @default.
• W4386796739 hasRelatedWork W2396120344 @default.
• W4386796739 hasRelatedWork W2429823055 @default.
• W4386796739 hasRelatedWork W2437213179 @default.
• W4386796739 hasRelatedWork W25059082 @default.
• W4386796739 hasVolume "124" @default.
• W4386796739 isParatext "false" @default.

• next