FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386799986> ?p ?o ?g. }

• W4386799986 abstract "Disseminated intravascular coagulation can occur due to different causes but commonly following sepsis. Trauma-induced coagulopathy (TIC) occurs on hospital arrival in approximately 25% of seriously injured patients who initially presents with impaired hemostasis and a bleeding phenotype that can later progress to a prothrombotic phase. Following traumatic injury, ineffective hemostasis is driven by massive blood loss, tissue damage, and hyperfibrinolysis. This initial impaired hemostasis continues until surgical or other management strategies not only to stop the causes of hemorrhage but also progresses to a prothrombotic and hypofibrinolytic state, also termed fibrinolytic shutdown. Prothrombotic progression is also promoted by inflammatory mediator release, endothelial injury, and platelet dysregulation, which is commonly seen in sepsis with increased mortality. Unlike TIC, the early phase of sepsis is frequently complicated by multiorgan dysfunction described as sepsis-induced coagulopathy (SIC) that lacks a hemorrhagic phase. The phenotypes of SIC and TIC are different, especially in their initial presentations; however, patients who survive TIC may also develop subsequent infections and potentially sepsis and SIC. Although the pathophysiology of SIC and TIC are different, endothelial injury, dysregulated fibrinolysis, and coagulation abnormalities are common. Management includes treatment of the underlying cause, tissue injury vs infection is critical, and supportive therapies, such as hemostatic resuscitation and circulatory support are essential, and adjunct therapies are recommended in guidelines. Based on clinical studies and certain guidelines, additional therapies include tranexamic acid in the limited timing of initial traumatic injury and anticoagulants, such as antithrombin and recombinant thrombomodulin in disseminated intravascular coagulation." @default.
• W4386799986 created "2023-09-17" @default.
• W4386799986 creator A5022890528 @default.
• W4386799986 creator A5023923739 @default.
• W4386799986 creator A5029058133 @default.
• W4386799986 creator A5053864173 @default.
• W4386799986 date "2023-09-01" @default.
• W4386799986 modified "2023-09-30" @default.
• W4386799986 title "Mechanisms and management of the coagulopathy of trauma and sepsis: TIC, SIC, and DIC" @default.
• W4386799986 cites W138422316 @default.
• W4386799986 cites W1969319463 @default.
• W4386799986 cites W1972347741 @default.
• W4386799986 cites W1989317042 @default.
• W4386799986 cites W1994516148 @default.
• W4386799986 cites W2017750793 @default.
• W4386799986 cites W2019584577 @default.
• W4386799986 cites W2038396793 @default.
• W4386799986 cites W2051426690 @default.
• W4386799986 cites W2072609921 @default.
• W4386799986 cites W2075182040 @default.
• W4386799986 cites W2082616171 @default.
• W4386799986 cites W2088106697 @default.
• W4386799986 cites W2097396264 @default.
• W4386799986 cites W2103008130 @default.
• W4386799986 cites W2104934425 @default.
• W4386799986 cites W2129887916 @default.
• W4386799986 cites W2156868786 @default.
• W4386799986 cites W2162249417 @default.
• W4386799986 cites W2211581164 @default.
• W4386799986 cites W2238441516 @default.
• W4386799986 cites W2276154749 @default.
• W4386799986 cites W2280404143 @default.
• W4386799986 cites W2410894778 @default.
• W4386799986 cites W2586773298 @default.
• W4386799986 cites W2613658506 @default.
• W4386799986 cites W2745119542 @default.
• W4386799986 cites W2753171978 @default.
• W4386799986 cites W2769886493 @default.
• W4386799986 cites W2794072059 @default.
• W4386799986 cites W2890479981 @default.
• W4386799986 cites W2897601525 @default.
• W4386799986 cites W2902310883 @default.
• W4386799986 cites W2904347322 @default.
• W4386799986 cites W2905635461 @default.
• W4386799986 cites W2932080593 @default.
• W4386799986 cites W2938462293 @default.
• W4386799986 cites W2942549919 @default.
• W4386799986 cites W2946106107 @default.
• W4386799986 cites W2946375103 @default.
• W4386799986 cites W2948313802 @default.
• W4386799986 cites W2953108625 @default.
• W4386799986 cites W2963387556 @default.
• W4386799986 cites W2967033240 @default.
• W4386799986 cites W2992658575 @default.
• W4386799986 cites W3011364498 @default.
• W4386799986 cites W3013413227 @default.
• W4386799986 cites W3024229651 @default.
• W4386799986 cites W3115857673 @default.
• W4386799986 cites W3195421991 @default.
• W4386799986 cites W3198645672 @default.
• W4386799986 cites W3212144275 @default.
• W4386799986 cites W335124151 @default.
• W4386799986 cites W4211237975 @default.
• W4386799986 cites W4226199543 @default.
• W4386799986 cites W4226438747 @default.
• W4386799986 cites W4283324702 @default.
• W4386799986 cites W4295755154 @default.
• W4386799986 cites W4312059083 @default.
• W4386799986 cites W4321185909 @default.
• W4386799986 doi "https://doi.org/10.1016/j.jtha.2023.05.028" @default.
• W4386799986 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37722532" @default.
• W4386799986 hasPublicationYear "2023" @default.
• W4386799986 type Work @default.
• W4386799986 citedByCount "0" @default.
• W4386799986 crossrefType "journal-article" @default.
• W4386799986 hasAuthorship W4386799986A5022890528 @default.
• W4386799986 hasAuthorship W4386799986A5023923739 @default.
• W4386799986 hasAuthorship W4386799986A5029058133 @default.
• W4386799986 hasAuthorship W4386799986A5053864173 @default.
• W4386799986 hasConcept C126322002 @default.
• W4386799986 hasConcept C177713679 @default.
• W4386799986 hasConcept C203014093 @default.
• W4386799986 hasConcept C2776825266 @default.
• W4386799986 hasConcept C2778384902 @default.
• W4386799986 hasConcept C2778589496 @default.
• W4386799986 hasConcept C2778734968 @default.
• W4386799986 hasConcept C2779936836 @default.
• W4386799986 hasConcept C2781219028 @default.
• W4386799986 hasConcept C71924100 @default.
• W4386799986 hasConceptScore W4386799986C126322002 @default.
• W4386799986 hasConceptScore W4386799986C177713679 @default.
• W4386799986 hasConceptScore W4386799986C203014093 @default.
• W4386799986 hasConceptScore W4386799986C2776825266 @default.
• W4386799986 hasConceptScore W4386799986C2778384902 @default.
• W4386799986 hasConceptScore W4386799986C2778589496 @default.
• W4386799986 hasConceptScore W4386799986C2778734968 @default.
• W4386799986 hasConceptScore W4386799986C2779936836 @default.
• W4386799986 hasConceptScore W4386799986C2781219028 @default.
• W4386799986 hasConceptScore W4386799986C71924100 @default.
• W4386799986 hasLocation W43867999861 @default.

• next