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• W4386800178 abstract "Protein products in hospitals often have to be compounded before administration to the patient. This may comprise reconstitution of lyophilizates, dilution, storage, and transport. However, the operations for compounding and administration in the hospital may lead to changes in product quality and possibly even impact patient safety. We surveyed healthcare practitioners from three clinical units using a questionnaire and open dialogue to document common procedures and their justification and to document differences in handling procedures. The survey covered dose compounding, transportation, storage and administration. One key observation was that drug vial optimization procedures were used for some products, e.g., use of one single-use vial for several patients. This included the use of spikes and needles or closed system transfer devices (CSTDs). Filters or light protection aids were used only when specified by the manufacturer. A further observation was a different handling of the overfill in pre-filled infusion containers, possibly impacting total dose. Lastly, we documented the complexity of infusion administration setups for administration of multiple drugs. In this case, flushing procedures or the placement and use of filters in the setup vary. Our study has revealed important differences in handling and administration practice. We propose that drug developers and hospitals should collaborate to establish unified handling procedures." @default.
• W4386800178 created "2023-09-17" @default.
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• W4386800178 date "2023-09-01" @default.
• W4386800178 modified "2023-10-13" @default.
• W4386800178 title "A survey on handling and administration of therapeutic protein products in German and Swiss hospitals" @default.
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• W4386800178 doi "https://doi.org/10.1016/j.xphs.2023.09.010" @default.
• W4386800178 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37722452" @default.
• W4386800178 hasPublicationYear "2023" @default.
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