Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386800404> ?p ?o ?g. }
- W4386800404 endingPage "114385" @default.
- W4386800404 startingPage "114385" @default.
- W4386800404 abstract "Hexane-acetyl acetate (HAAF) and acetyl acetate-methanol fractions (AAMF) but not aqueous methanol (AQMF) and aqueous fractions (AQF) of Adansonia digitata Linn root bark induce reproductive effects in female Wistar rats. The current study investigated the exclusive components of HAAF, AAMF, AQMF, and AQF of Adansonia digitata Linn root bark and the effect of AAMF on the female Wistar rat's oestrous cycle progression, and hormone and lipid profiles.Gas chromatography and mass spectrometry explored the components of HAAF, AAMF, AQMF, and AQF. Mature female Wistar rats with a proven 4-5-days oestrous cycle were synchronised and randomly assigned into three treatment groups of 30 rats each on the day of proestrus. For seven days, rats in the different groups received 0, 150, and 300 mg kg-1 body weights of AAMF, respectively. Six rats were euthanised from each group based on a standard oestrous stage-timed sequence. The oestrous stage, hormone profile (oestrogen, progesterone, progesterone/oestrogen ratio, and FSH) and lipid profile (Total cholesterol-TC, Triglycerols, High-HD and low density-LD lipid cholesterol) of the euthanised rats were determined.tricosene, cyclopentadecanone 2-hydroxy-, oleic acid, and 9,17-octadecadienal, were exclusively found in HAAF and AAMF. The oestrous stage, serum hormone and lipids varied significantly (p < 0.05) between treatment groups. AAMF fraction induced sustained progesterone levels and depleted oestrogen levels, and TC and LDL were inversely related to serum oestrogen levels.The results suggest a depression of oestrogen and sustenance of progesterone-mediated effects, respectively, on GnRH surge. Oleic acid in AAMF may be responsible for its reproductive effects.AAMF fraction of A. digitata (L) root bark disrupts the endocrine activity in female Wistar rats. The oleic acid component of the AAMF fraction may be responsible for modulating the activities of reproductive hormones. The authors recommend further studies to ascertain the significance of Adansonia digitata extract's oleic acid in regulating the female reproductive cycle." @default.
- W4386800404 created "2023-09-17" @default.
- W4386800404 creator A5009130594 @default.
- W4386800404 creator A5011741355 @default.
- W4386800404 creator A5036688013 @default.
- W4386800404 creator A5074425419 @default.
- W4386800404 creator A5091727865 @default.
- W4386800404 creator A5092887123 @default.
- W4386800404 date "2023-12-01" @default.
- W4386800404 modified "2023-10-09" @default.
- W4386800404 title "Endocrine disruptors in Adansonia digitata (Linn) extract induce alteration of female Wistar rats’ oestrous cycle, hormone and lipid profiles" @default.
- W4386800404 cites W1583177431 @default.
- W4386800404 cites W1975461839 @default.
- W4386800404 cites W1986821460 @default.
- W4386800404 cites W2012449992 @default.
- W4386800404 cites W2021499689 @default.
- W4386800404 cites W2027971172 @default.
- W4386800404 cites W2035549111 @default.
- W4386800404 cites W2043659942 @default.
- W4386800404 cites W2047112602 @default.
- W4386800404 cites W2049547522 @default.
- W4386800404 cites W2057313063 @default.
- W4386800404 cites W2059971848 @default.
- W4386800404 cites W2069403965 @default.
- W4386800404 cites W2084816353 @default.
- W4386800404 cites W2090423940 @default.
- W4386800404 cites W2096022216 @default.
- W4386800404 cites W2107251490 @default.
- W4386800404 cites W2117165886 @default.
- W4386800404 cites W2118614484 @default.
- W4386800404 cites W2137009721 @default.
- W4386800404 cites W2137843473 @default.
- W4386800404 cites W2146216925 @default.
- W4386800404 cites W2146853018 @default.
- W4386800404 cites W2164640247 @default.
- W4386800404 cites W2168290191 @default.
- W4386800404 cites W2277807860 @default.
- W4386800404 cites W2345142332 @default.
- W4386800404 cites W2409420700 @default.
- W4386800404 cites W2528243563 @default.
- W4386800404 cites W2616454579 @default.
- W4386800404 cites W2744057784 @default.
- W4386800404 cites W2753014543 @default.
- W4386800404 cites W2762267668 @default.
- W4386800404 cites W2788051887 @default.
- W4386800404 cites W2800244712 @default.
- W4386800404 cites W2895188118 @default.
- W4386800404 cites W2950943972 @default.
- W4386800404 cites W4210931812 @default.
- W4386800404 cites W4232972358 @default.
- W4386800404 cites W4238754411 @default.
- W4386800404 doi "https://doi.org/10.1016/j.ygcen.2023.114385" @default.
- W4386800404 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37722461" @default.
- W4386800404 hasPublicationYear "2023" @default.
- W4386800404 type Work @default.
- W4386800404 citedByCount "0" @default.
- W4386800404 crossrefType "journal-article" @default.
- W4386800404 hasAuthorship W4386800404A5009130594 @default.
- W4386800404 hasAuthorship W4386800404A5011741355 @default.
- W4386800404 hasAuthorship W4386800404A5036688013 @default.
- W4386800404 hasAuthorship W4386800404A5074425419 @default.
- W4386800404 hasAuthorship W4386800404A5091727865 @default.
- W4386800404 hasAuthorship W4386800404A5092887123 @default.
- W4386800404 hasConcept C126322002 @default.
- W4386800404 hasConcept C134018914 @default.
- W4386800404 hasConcept C1998276 @default.
- W4386800404 hasConcept C2781403372 @default.
- W4386800404 hasConcept C2908808681 @default.
- W4386800404 hasConcept C59822182 @default.
- W4386800404 hasConcept C71315377 @default.
- W4386800404 hasConcept C71924100 @default.
- W4386800404 hasConcept C86803240 @default.
- W4386800404 hasConceptScore W4386800404C126322002 @default.
- W4386800404 hasConceptScore W4386800404C134018914 @default.
- W4386800404 hasConceptScore W4386800404C1998276 @default.
- W4386800404 hasConceptScore W4386800404C2781403372 @default.
- W4386800404 hasConceptScore W4386800404C2908808681 @default.
- W4386800404 hasConceptScore W4386800404C59822182 @default.
- W4386800404 hasConceptScore W4386800404C71315377 @default.
- W4386800404 hasConceptScore W4386800404C71924100 @default.
- W4386800404 hasConceptScore W4386800404C86803240 @default.
- W4386800404 hasLocation W43868004041 @default.
- W4386800404 hasLocation W43868004042 @default.
- W4386800404 hasOpenAccess W4386800404 @default.
- W4386800404 hasPrimaryLocation W43868004041 @default.
- W4386800404 hasRelatedWork W2059103492 @default.
- W4386800404 hasRelatedWork W2102973145 @default.
- W4386800404 hasRelatedWork W2748952813 @default.
- W4386800404 hasRelatedWork W3033592159 @default.
- W4386800404 hasRelatedWork W3176485055 @default.
- W4386800404 hasRelatedWork W4249489946 @default.
- W4386800404 hasRelatedWork W4362696202 @default.
- W4386800404 hasRelatedWork W4366990380 @default.
- W4386800404 hasRelatedWork W145443172 @default.
- W4386800404 hasRelatedWork W2288693268 @default.
- W4386800404 hasVolume "344" @default.
- W4386800404 isParatext "false" @default.
- W4386800404 isRetracted "false" @default.