FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386800825> ?p ?o ?g. }

• W4386800825 abstract "Undernutrition in pregnant women is an unfavorable environmental condition that can affect the intrauterine development via epigenetic mechanisms and thus have long-lasting detrimental consequences for the mental health of the offspring later in life. One epigenetic mechanism that has been associated with mental disorders and undernutrition is alterations in DNA methylation. The effect of prenatal undernutrition on the mental health of adult offspring can be analyzed through quasi-experimental studies such as famine studies. The present systematic review and meta-analysis aims to analyze the association between prenatal famine exposure, DNA methylation, and mental disorders in adult offspring. We further investigate whether altered DNA methylation as a result of prenatal famine exposure is prospectively linked to mental disorders.We conducted a systematic search of the databases PubMed and PsycINFO to identify relevant records up to September 2022 on offspring whose mothers experienced famine directly before and/or during pregnancy, examining the impact of prenatal famine exposure on the offspring's DNA methylation and/or mental disorders or symptoms.The systematic review showed that adults who were prenatally exposed to famine had an increased risk of schizophrenia and depression. Several studies reported an association between prenatal famine exposure and hyper- or hypomethylation of specific genes. The largest number of studies reported differences in DNA methylation of the IGF2 gene. Altered DNA methylation of the DUSP22 gene mediated the association between prenatal famine exposure and schizophrenia in adult offspring. Meta-analysis confirmed the increased risk of schizophrenia following prenatal famine exposure. For DNA methylation, meta-analysis was not suitable due to different microarrays/data processing approaches and/or unavailable data.Prenatal famine exposure is associated with an increased risk of mental disorders and DNA methylation changes. The findings suggest that changes in DNA methylation of genes involved in neuronal, neuroendocrine, and immune processes may be a mechanism that promotes the development of mental disorders such as schizophrenia and depression in adult offspring. Such findings are crucial given that undernutrition has risen worldwide, increasing the risk of famine and thus also of negative effects on mental health." @default.
• W4386800825 created "2023-09-17" @default.
• W4386800825 creator A5049414539 @default.
• W4386800825 creator A5092467354 @default.
• W4386800825 date "2023-09-16" @default.
• W4386800825 modified "2023-10-16" @default.
• W4386800825 title "The association between prenatal famine, DNA methylation and mental disorders: a systematic review and meta-analysis" @default.
• W4386800825 cites W1732425222 @default.
• W4386800825 cites W1749255537 @default.
• W4386800825 cites W1821797507 @default.
• W4386800825 cites W1851806939 @default.
• W4386800825 cites W1907676424 @default.
• W4386800825 cites W1965672724 @default.
• W4386800825 cites W1966866532 @default.
• W4386800825 cites W1971639265 @default.
• W4386800825 cites W1973685382 @default.
• W4386800825 cites W1981961740 @default.
• W4386800825 cites W1983365668 @default.
• W4386800825 cites W1984004239 @default.
• W4386800825 cites W1988161295 @default.
• W4386800825 cites W1991608111 @default.
• W4386800825 cites W1993206740 @default.
• W4386800825 cites W1995362640 @default.
• W4386800825 cites W1997402206 @default.
• W4386800825 cites W2007636259 @default.
• W4386800825 cites W2010390756 @default.
• W4386800825 cites W2018647656 @default.
• W4386800825 cites W2018983090 @default.
• W4386800825 cites W2019787559 @default.
• W4386800825 cites W2026840823 @default.
• W4386800825 cites W2030295018 @default.
• W4386800825 cites W2031783923 @default.
• W4386800825 cites W2033585778 @default.
• W4386800825 cites W2041042823 @default.
• W4386800825 cites W2042914870 @default.
• W4386800825 cites W2046314520 @default.
• W4386800825 cites W2046645276 @default.
• W4386800825 cites W2058184727 @default.
• W4386800825 cites W2067255906 @default.
• W4386800825 cites W2074647644 @default.
• W4386800825 cites W2084680588 @default.
• W4386800825 cites W2085791754 @default.
• W4386800825 cites W2087504933 @default.
• W4386800825 cites W2090515073 @default.
• W4386800825 cites W2096329739 @default.
• W4386800825 cites W2101062288 @default.
• W4386800825 cites W2101526557 @default.
• W4386800825 cites W2103869399 @default.
• W4386800825 cites W2106670153 @default.
• W4386800825 cites W2109112922 @default.
• W4386800825 cites W2112349283 @default.
• W4386800825 cites W2112629544 @default.
• W4386800825 cites W2115460495 @default.
• W4386800825 cites W2116772407 @default.
• W4386800825 cites W2116958649 @default.
• W4386800825 cites W2118690620 @default.
• W4386800825 cites W2119135444 @default.
• W4386800825 cites W2120658378 @default.
• W4386800825 cites W2123308453 @default.
• W4386800825 cites W2124317383 @default.
• W4386800825 cites W2128109383 @default.
• W4386800825 cites W2132748057 @default.
• W4386800825 cites W2143858605 @default.
• W4386800825 cites W2145098771 @default.
• W4386800825 cites W2145975061 @default.
• W4386800825 cites W2148062286 @default.
• W4386800825 cites W2148462747 @default.
• W4386800825 cites W2152497434 @default.
• W4386800825 cites W2153154318 @default.
• W4386800825 cites W2161187682 @default.
• W4386800825 cites W2163570431 @default.
• W4386800825 cites W2167015768 @default.
• W4386800825 cites W2170858752 @default.
• W4386800825 cites W2256732880 @default.
• W4386800825 cites W2304496028 @default.
• W4386800825 cites W2329888282 @default.
• W4386800825 cites W2416989675 @default.
• W4386800825 cites W2513373784 @default.
• W4386800825 cites W2529024004 @default.
• W4386800825 cites W2551024407 @default.
• W4386800825 cites W2556069014 @default.
• W4386800825 cites W2591679458 @default.
• W4386800825 cites W2610758860 @default.
• W4386800825 cites W2616824408 @default.
• W4386800825 cites W2631752818 @default.
• W4386800825 cites W2741685835 @default.
• W4386800825 cites W2760464541 @default.
• W4386800825 cites W2760915792 @default.
• W4386800825 cites W2763350837 @default.
• W4386800825 cites W2766930649 @default.
• W4386800825 cites W2767741810 @default.
• W4386800825 cites W2790306871 @default.
• W4386800825 cites W2791267420 @default.
• W4386800825 cites W2792504624 @default.
• W4386800825 cites W2798203270 @default.
• W4386800825 cites W2800807006 @default.
• W4386800825 cites W2802228122 @default.
• W4386800825 cites W2810410351 @default.
• W4386800825 cites W2887095806 @default.
• W4386800825 cites W2887561905 @default.

• next