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• W4386800856 abstract "The α-adrenoreceptor agonist dexmedetomidine is increasingly used as a 2osedative-hypnotic and analgesic agent, but with this popularity come concerns about the side effects of the drug. Bradycardia and hypotension are common adverse effects, but there are also several reports of excessive urine output, possibly due to vasopressin secretion and permeability of collecting ducts. Polyuria usually resolves with discontinuation of the drug, and significant morbidity has not been reported. Early identification, removal of the agent, and treatment are imperative to minimize complications - mainly natremia and neurological symptoms. This case report describes dexmedetomidine-related polyuria during opioid-free general anaesthesia for major head and neck surgery. Our hypothesis of a nephrogenic aetiology is reinforced by the analytical data obtained. We also describe our approach to intra-operative polyuria. El agonismo de los receptores adrenérgicos α de la dexmedetomidina ha ido ganando popularidad en la sala de anestesia como agente sedante-hipnótico y analgésico, y con el uso perioperatorio extenso es necesaria una creciente preocupación por los efectos secundarios. La bradicardia y la hipotensión son frecuentes, pero se informa cada vez más de una diuresis excesiva, siendo los mecanismos sugeridos la secreción de vasopresina y el aumento de la permeabilidad de los conductos colectores. La poliuria generalmente se resuelve con la suspensión del fármaco y no se ha informado morbilidad significativa. La identificación temprana, la eliminación del agente y el tratamiento son imprescindibles para minimizar las complicaciones, principalmente asociadas con los niveles de natremia y los síntomas neurológicos. Este informe de caso describe un síndrome poliúrico relacionado con la dexmedetomidina durante la anestesia general sin opioides para una cirugía mayor de cabeza y cuello. Se propone un mecanismo nefrogénico para el efecto clínico y se refuerza con los datos analíticos obtenidos. También se describe un enfoque de poliuria intraoperatoria." @default.
• W4386800856 created "2023-09-17" @default.
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• W4386800856 date "2023-09-01" @default.
• W4386800856 modified "2023-10-03" @default.
• W4386800856 title "A nephrogenic mechanism underlies dexmedetomidine-induced polyuria. A case report" @default.
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• W4386800856 doi "https://doi.org/10.1016/j.redare.2022.10.012" @default.
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