Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386802516> ?p ?o ?g. }
- W4386802516 abstract "In recent years, major advances have been made toward the individualization of epithelial ovarian cancer care, leading to an overall improvement of patient outcomes. However, real-life data indicate that the oldest populations do not benefit from this, due to aspects related to cancer (more aggressive histopathological features), treatment (i.e. frequently suboptimal), and the host (increased toxicities in patients with lower physiological reserve). A specific risk–benefit perspective should therefore be taken when considering surgery, chemotherapy, and maintenance treatments: the decision for cytoreductive surgery should include geriatric vulnerability and surgical complexity, neo-adjuvant chemotherapy being an option when primary surgery appears at high risk; carboplatin paclitaxel association remains the standard even in vulnerable older patients; and bevacizumab and poly(ADP-ribose) polymerase inhibitors maintenance are interesting options provided they are prescribed according to their indications with a close monitoring of their toxicities. Future studies should aim to individualize care without limiting access of older patients to innovation. A specific focus is needed on age-specific translational analyses (focusing on tumor mutational burden and impaired biological pathways), a better patient stratification according to geriatric parameters, an adaptation of both oncological treatment and geriatric interventions, and treatment adaptations not a priori but according to formal pharmacokinetic data." @default.
- W4386802516 created "2023-09-17" @default.
- W4386802516 creator A5001891158 @default.
- W4386802516 creator A5006716940 @default.
- W4386802516 creator A5034431552 @default.
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- W4386802516 creator A5078533276 @default.
- W4386802516 creator A5086294065 @default.
- W4386802516 creator A5088879599 @default.
- W4386802516 date "2023-01-01" @default.
- W4386802516 modified "2023-10-14" @default.
- W4386802516 title "Ovarian cancer in the older patient: where are we now? What to do next?" @default.
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