Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386803153> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W4386803153 abstract "Liver cancer is a highly lethal and aggressive form of cancer that poses a significant threat to patient survival. Within this category, liver hepatocellular carcinoma (LIHC) represents the most common subtype of liver cancer. Despite decades of research and treatment, the overall survival rate for LIHC has not significantly improved. Improved models are necessary to differentiate high-risk cases and predict possible treatment options for LIHC patients. Recent studies have identified a set of genes associated with neutrophil extracellular traps (NETs) that may contribute to tumor growth and metastasis; however, their prognostic value in LIHC has yet to be established. This study aims to construct a prognostic signature based on a set of NET-related genes (NRGs) for patients diagnosed with LIHC.The transcriptomic data and clinical information concerning LIHC patients were procured from the Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium LIHC (ICLIHC) databases, respectively. To determine the NRG subtypes, the k-means algorithm was employed, along with consensus clustering. The aforementioned analysis aided the construction of a prognostic signature utilizing the last absolute shrinkage and selection operator Cox analysis. To validate the prognostic model, an external dataset, receiver operating characteristic curve, and principal component analysis were utilized. Moreover, the immune microenvironment and the proportion of immune cells between high- and low-risk cases were scrutinized by ESTIMATE and CIBERSORT algorithms. Finally, gene set enrichment analysis was executed to investigate the potential mechanism of NRGs in the pathogenesis and prognosis of LIHC.Two molecular subtypes of LIHC were identified based on the expression patterns of differentially expressed NRGs (DE-NRGs). The two subtypes demonstrated significant differences in survival rates and immune cell expression levels. The study results demonstrated the role of NRGs in antigen presentation, which led to the promotion of tumor immune escape. A risk model was developed and validated with strong overall survival prediction ability. The model, comprising 34 NRGs, showed a strong ability to predict prognosis.We built a dependable prognostic signature based on NRGs for LIHC. We identified that NRGs could have a significant interaction in LIHC's immune microenvironment and therapeutic response. This finding offers insight into the molecular mechanisms and targeted therapy for LIHC." @default.
- W4386803153 created "2023-09-17" @default.
- W4386803153 creator A5022272694 @default.
- W4386803153 creator A5033332279 @default.
- W4386803153 creator A5061115290 @default.
- W4386803153 creator A5065002010 @default.
- W4386803153 creator A5068545986 @default.
- W4386803153 date "2023-09-16" @default.
- W4386803153 modified "2023-09-26" @default.
- W4386803153 title "A signature based on neutrophil extracellular trap‐related genes for the assessment of prognosis, immunoinfiltration, mutation and therapeutic response in hepatocellular carcinoma" @default.
- W4386803153 cites W1976782874 @default.
- W4386803153 cites W1985987855 @default.
- W4386803153 cites W2115462905 @default.
- W4386803153 cites W2130410032 @default.
- W4386803153 cites W2130430382 @default.
- W4386803153 cites W2406250479 @default.
- W4386803153 cites W2983258509 @default.
- W4386803153 cites W2985042999 @default.
- W4386803153 cites W2996314623 @default.
- W4386803153 cites W2999216937 @default.
- W4386803153 cites W3036371598 @default.
- W4386803153 cites W3084567979 @default.
- W4386803153 cites W3107527779 @default.
- W4386803153 cites W3134287650 @default.
- W4386803153 cites W4225400555 @default.
- W4386803153 cites W4229030785 @default.
- W4386803153 cites W4291020217 @default.
- W4386803153 cites W4301390461 @default.
- W4386803153 cites W4307871399 @default.
- W4386803153 cites W4366292992 @default.
- W4386803153 cites W4382777066 @default.
- W4386803153 cites W4383621083 @default.
- W4386803153 doi "https://doi.org/10.1002/jgm.3588" @default.
- W4386803153 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37715643" @default.
- W4386803153 hasPublicationYear "2023" @default.
- W4386803153 type Work @default.
- W4386803153 citedByCount "0" @default.
- W4386803153 crossrefType "journal-article" @default.
- W4386803153 hasAuthorship W4386803153A5022272694 @default.
- W4386803153 hasAuthorship W4386803153A5033332279 @default.
- W4386803153 hasAuthorship W4386803153A5061115290 @default.
- W4386803153 hasAuthorship W4386803153A5065002010 @default.
- W4386803153 hasAuthorship W4386803153A5068545986 @default.
- W4386803153 hasBestOaLocation W43868031531 @default.
- W4386803153 hasConcept C104317684 @default.
- W4386803153 hasConcept C10515644 @default.
- W4386803153 hasConcept C121608353 @default.
- W4386803153 hasConcept C126322002 @default.
- W4386803153 hasConcept C141231307 @default.
- W4386803153 hasConcept C150194340 @default.
- W4386803153 hasConcept C162317418 @default.
- W4386803153 hasConcept C203014093 @default.
- W4386803153 hasConcept C2776231280 @default.
- W4386803153 hasConcept C2778019345 @default.
- W4386803153 hasConcept C502942594 @default.
- W4386803153 hasConcept C54355233 @default.
- W4386803153 hasConcept C70721500 @default.
- W4386803153 hasConcept C71924100 @default.
- W4386803153 hasConcept C86803240 @default.
- W4386803153 hasConcept C8891405 @default.
- W4386803153 hasConceptScore W4386803153C104317684 @default.
- W4386803153 hasConceptScore W4386803153C10515644 @default.
- W4386803153 hasConceptScore W4386803153C121608353 @default.
- W4386803153 hasConceptScore W4386803153C126322002 @default.
- W4386803153 hasConceptScore W4386803153C141231307 @default.
- W4386803153 hasConceptScore W4386803153C150194340 @default.
- W4386803153 hasConceptScore W4386803153C162317418 @default.
- W4386803153 hasConceptScore W4386803153C203014093 @default.
- W4386803153 hasConceptScore W4386803153C2776231280 @default.
- W4386803153 hasConceptScore W4386803153C2778019345 @default.
- W4386803153 hasConceptScore W4386803153C502942594 @default.
- W4386803153 hasConceptScore W4386803153C54355233 @default.
- W4386803153 hasConceptScore W4386803153C70721500 @default.
- W4386803153 hasConceptScore W4386803153C71924100 @default.
- W4386803153 hasConceptScore W4386803153C86803240 @default.
- W4386803153 hasConceptScore W4386803153C8891405 @default.
- W4386803153 hasLocation W43868031531 @default.
- W4386803153 hasLocation W43868031532 @default.
- W4386803153 hasOpenAccess W4386803153 @default.
- W4386803153 hasPrimaryLocation W43868031531 @default.
- W4386803153 hasRelatedWork W1603543036 @default.
- W4386803153 hasRelatedWork W1992278374 @default.
- W4386803153 hasRelatedWork W2020483997 @default.
- W4386803153 hasRelatedWork W2027663190 @default.
- W4386803153 hasRelatedWork W2919381586 @default.
- W4386803153 hasRelatedWork W2983818379 @default.
- W4386803153 hasRelatedWork W3000738194 @default.
- W4386803153 hasRelatedWork W3025961873 @default.
- W4386803153 hasRelatedWork W4285006390 @default.
- W4386803153 hasRelatedWork W4286500138 @default.
- W4386803153 isParatext "false" @default.
- W4386803153 isRetracted "false" @default.
- W4386803153 workType "article" @default.