FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386808410> ?p ?o ?g. }

• W4386808410 abstract "Neuroligin 4 X-linked (NLGN4X) harbors a human leukocyte antigen (HLA)-A2-restricted tumor-associated antigen, overexpressed in human gliomas, that was found to induce specific cytotoxic T cell responses following multi-peptide vaccination in patients with newly- diagnosed glioblastoma.T cell receptor (TCR) discovery was performed using droplet-based single cell TCR sequencing of NLGN4X-tetramer-sorted T cells post vaccination. The identified TCR was delivered to Jurkat T cells and primary human T cells (NLGN4X-TCR-T). Functional profiling of NLGN4X-TCR-T was performed by flow cytometry and cytotoxicity assays. Therapeutic efficacy of intracerebroventricular NLGN4X-TCR-T was assessed in NOD scid gamma (NSG) major histocompatibility complex (MHC) I/II knockout (KO) (NSG MHC I/II KO) mice bearing NLGN4X-expressing experimental gliomas.An HLA-A *02-restricted vaccine-induced T cell receptor specifically binding NLGN4X131-139 was applied for therapeutic use. Reactivity, cytotoxicity, and polyfunctionality of this NLGN4X-specific TCR is demonstrated in various cellular models. Intracerebroventricular administration of NLGN4X-TCR-T prolongs survival and leads to an objective response rate (ORR) of 44.4 % in experimental gliomas-bearing NSG MHC I/II KO mice compared to 0.0 % in control groups, respectively.NLGN4X-TCR-T demonstrates efficacy in a preclinical glioblastoma model. On a global scale, we provide first evidence for the therapeutic retrieval of vaccine-induced human TCRs for the off-the-shelf treatment of glioblastoma patients." @default.
• W4386808410 created "2023-09-17" @default.
• W4386808410 creator A5003448975 @default.
• W4386808410 creator A5010085093 @default.
• W4386808410 creator A5012664726 @default.
• W4386808410 creator A5018374375 @default.
• W4386808410 creator A5023241631 @default.
• W4386808410 creator A5026069456 @default.
• W4386808410 creator A5028412110 @default.
• W4386808410 creator A5036394378 @default.
• W4386808410 creator A5041264974 @default.
• W4386808410 creator A5042911510 @default.
• W4386808410 creator A5045908539 @default.
• W4386808410 creator A5049460850 @default.
• W4386808410 creator A5064778456 @default.
• W4386808410 creator A5080482957 @default.
• W4386808410 creator A5084128727 @default.
• W4386808410 creator A5084378178 @default.
• W4386808410 creator A5085683988 @default.
• W4386808410 creator A5086447842 @default.
• W4386808410 creator A5089187345 @default.
• W4386808410 creator A5092889951 @default.
• W4386808410 date "2023-09-16" @default.
• W4386808410 modified "2023-10-12" @default.
• W4386808410 title "NLGN4X TCR transgenic T cells to treat gliomas" @default.
• W4386808410 cites W1983143892 @default.
• W4386808410 cites W2013775888 @default.
• W4386808410 cites W2014698000 @default.
• W4386808410 cites W2064352628 @default.
• W4386808410 cites W2070748533 @default.
• W4386808410 cites W2078461037 @default.
• W4386808410 cites W2094652659 @default.
• W4386808410 cites W2098433544 @default.
• W4386808410 cites W2105879190 @default.
• W4386808410 cites W2147152912 @default.
• W4386808410 cites W2154115071 @default.
• W4386808410 cites W2528386527 @default.
• W4386808410 cites W2567424265 @default.
• W4386808410 cites W2577801124 @default.
• W4386808410 cites W2605626471 @default.
• W4386808410 cites W2738678436 @default.
• W4386808410 cites W2773406691 @default.
• W4386808410 cites W2904210127 @default.
• W4386808410 cites W2940767284 @default.
• W4386808410 cites W2953716731 @default.
• W4386808410 cites W2954542121 @default.
• W4386808410 cites W2982049472 @default.
• W4386808410 cites W2987601351 @default.
• W4386808410 cites W3017825580 @default.
• W4386808410 cites W3019060111 @default.
• W4386808410 cites W3092444112 @default.
• W4386808410 cites W3157520262 @default.
• W4386808410 cites W3178970276 @default.
• W4386808410 cites W3189362000 @default.
• W4386808410 cites W3217375043 @default.
• W4386808410 cites W4210924686 @default.
• W4386808410 cites W4225630787 @default.
• W4386808410 cites W4226128806 @default.
• W4386808410 cites W4294679595 @default.
• W4386808410 cites W4306795470 @default.
• W4386808410 cites W4307639681 @default.
• W4386808410 cites W4311584464 @default.
• W4386808410 doi "https://doi.org/10.1093/neuonc/noad172" @default.
• W4386808410 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37715782" @default.
• W4386808410 hasPublicationYear "2023" @default.
• W4386808410 type Work @default.
• W4386808410 citedByCount "0" @default.
• W4386808410 crossrefType "journal-article" @default.
• W4386808410 hasAuthorship W4386808410A5003448975 @default.
• W4386808410 hasAuthorship W4386808410A5010085093 @default.
• W4386808410 hasAuthorship W4386808410A5012664726 @default.
• W4386808410 hasAuthorship W4386808410A5018374375 @default.
• W4386808410 hasAuthorship W4386808410A5023241631 @default.
• W4386808410 hasAuthorship W4386808410A5026069456 @default.
• W4386808410 hasAuthorship W4386808410A5028412110 @default.
• W4386808410 hasAuthorship W4386808410A5036394378 @default.
• W4386808410 hasAuthorship W4386808410A5041264974 @default.
• W4386808410 hasAuthorship W4386808410A5042911510 @default.
• W4386808410 hasAuthorship W4386808410A5045908539 @default.
• W4386808410 hasAuthorship W4386808410A5049460850 @default.
• W4386808410 hasAuthorship W4386808410A5064778456 @default.
• W4386808410 hasAuthorship W4386808410A5080482957 @default.
• W4386808410 hasAuthorship W4386808410A5084128727 @default.
• W4386808410 hasAuthorship W4386808410A5084378178 @default.
• W4386808410 hasAuthorship W4386808410A5085683988 @default.
• W4386808410 hasAuthorship W4386808410A5086447842 @default.
• W4386808410 hasAuthorship W4386808410A5089187345 @default.
• W4386808410 hasAuthorship W4386808410A5092889951 @default.
• W4386808410 hasBestOaLocation W43868084101 @default.
• W4386808410 hasConcept C109316439 @default.
• W4386808410 hasConcept C147483822 @default.
• W4386808410 hasConcept C153911025 @default.
• W4386808410 hasConcept C154317977 @default.
• W4386808410 hasConcept C19317047 @default.
• W4386808410 hasConcept C202751555 @default.
• W4386808410 hasConcept C203014093 @default.
• W4386808410 hasConcept C207936829 @default.
• W4386808410 hasConcept C2776090121 @default.
• W4386808410 hasConcept C2777701055 @default.
• W4386808410 hasConcept C502942594 @default.

• next