Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386810318> ?p ?o ?g. }
- W4386810318 abstract "Abstract Adaptive immunity is generated in lymphoid organs, but how these structures defend themselves during infection in humans is unknown. The nasal epithelium is a major site of viral entry, with adenoid nasal-associated lymphoid tissue (NALT) generating early adaptive responses. Here, using a nasopharyngeal biopsy, we examined longitudinal immune responses in NALT following viral challenge, using SARS-CoV-2 infection as a natural experimental model. In acute infection, infiltrating monocytes formed a subepithelial and peri-follicular shield, recruiting NET-forming neutrophils, whilst tissue macrophages expressed pro-repair molecules during convalescence to promote the restoration of tissue integrity. Germinal centre B cells expressed anti-viral transcripts that inversely correlated with fate-defining transcription factors. Among T cells, tissue-resident memory CD8 T cells alone showed clonal expansion and maintained cytotoxic transcriptional programmes into convalescence. Together our study provides a unique insight into how human nasal adaptive immune responses are generated and sustained in the face of viral challenge." @default.
- W4386810318 created "2023-09-18" @default.
- W4386810318 creator A5007826002 @default.
- W4386810318 creator A5013370884 @default.
- W4386810318 creator A5015495745 @default.
- W4386810318 creator A5017642260 @default.
- W4386810318 creator A5023913768 @default.
- W4386810318 creator A5025228115 @default.
- W4386810318 creator A5034389766 @default.
- W4386810318 creator A5073854606 @default.
- W4386810318 creator A5082524136 @default.
- W4386810318 creator A5083952934 @default.
- W4386810318 creator A5088908508 @default.
- W4386810318 date "2023-09-17" @default.
- W4386810318 modified "2023-09-29" @default.
- W4386810318 title "Temporal profiling of human lymphoid tissues reveals coordinated defence to viral challenge" @default.
- W4386810318 cites W1552348610 @default.
- W4386810318 cites W1602916344 @default.
- W4386810318 cites W1678411211 @default.
- W4386810318 cites W1986120120 @default.
- W4386810318 cites W1997241837 @default.
- W4386810318 cites W2013635745 @default.
- W4386810318 cites W2016054852 @default.
- W4386810318 cites W2016175731 @default.
- W4386810318 cites W2019206924 @default.
- W4386810318 cites W2056652025 @default.
- W4386810318 cites W2062690397 @default.
- W4386810318 cites W2069089843 @default.
- W4386810318 cites W2071380288 @default.
- W4386810318 cites W2071536249 @default.
- W4386810318 cites W2075689961 @default.
- W4386810318 cites W2081613377 @default.
- W4386810318 cites W2082595913 @default.
- W4386810318 cites W2087310005 @default.
- W4386810318 cites W2087683936 @default.
- W4386810318 cites W2103793744 @default.
- W4386810318 cites W2104934425 @default.
- W4386810318 cites W2130410032 @default.
- W4386810318 cites W2133951067 @default.
- W4386810318 cites W2148749566 @default.
- W4386810318 cites W2156658768 @default.
- W4386810318 cites W2162166699 @default.
- W4386810318 cites W2168176302 @default.
- W4386810318 cites W2170805498 @default.
- W4386810318 cites W2214074259 @default.
- W4386810318 cites W2239291357 @default.
- W4386810318 cites W2620974035 @default.
- W4386810318 cites W2737196618 @default.
- W4386810318 cites W2788546163 @default.
- W4386810318 cites W2800392236 @default.
- W4386810318 cites W2801235164 @default.
- W4386810318 cites W2817838603 @default.
- W4386810318 cites W2907514116 @default.
- W4386810318 cites W2911922390 @default.
- W4386810318 cites W2914178563 @default.
- W4386810318 cites W2941351281 @default.
- W4386810318 cites W2949177718 @default.
- W4386810318 cites W2951799803 @default.
- W4386810318 cites W2979687060 @default.
- W4386810318 cites W2984472267 @default.
- W4386810318 cites W2989807288 @default.
- W4386810318 cites W3007935255 @default.
- W4386810318 cites W3008827533 @default.
- W4386810318 cites W3020331344 @default.
- W4386810318 cites W3024643080 @default.
- W4386810318 cites W3040048187 @default.
- W4386810318 cites W3040324319 @default.
- W4386810318 cites W3048884493 @default.
- W4386810318 cites W3049048202 @default.
- W4386810318 cites W3049166744 @default.
- W4386810318 cites W3087442002 @default.
- W4386810318 cites W3099862724 @default.
- W4386810318 cites W3106188259 @default.
- W4386810318 cites W3114092281 @default.
- W4386810318 cites W3121168830 @default.
- W4386810318 cites W3128961456 @default.
- W4386810318 cites W3139190700 @default.
- W4386810318 cites W3150635270 @default.
- W4386810318 cites W3153732845 @default.
- W4386810318 cites W3163104912 @default.
- W4386810318 cites W3164692211 @default.
- W4386810318 cites W3193480463 @default.
- W4386810318 cites W3206370075 @default.
- W4386810318 cites W4200289086 @default.
- W4386810318 cites W4205428045 @default.
- W4386810318 cites W4205846032 @default.
- W4386810318 cites W4212947943 @default.
- W4386810318 cites W4220939068 @default.
- W4386810318 cites W4226075435 @default.
- W4386810318 cites W4312019644 @default.
- W4386810318 cites W72880836 @default.
- W4386810318 doi "https://doi.org/10.1101/2023.09.15.558006" @default.
- W4386810318 hasPublicationYear "2023" @default.
- W4386810318 type Work @default.
- W4386810318 citedByCount "0" @default.
- W4386810318 crossrefType "posted-content" @default.
- W4386810318 hasAuthorship W4386810318A5007826002 @default.
- W4386810318 hasAuthorship W4386810318A5013370884 @default.
- W4386810318 hasAuthorship W4386810318A5015495745 @default.
- W4386810318 hasAuthorship W4386810318A5017642260 @default.