FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386811706> ?p ?o ?g. }

• W4386811706 abstract "Background The Langendorff-perfused ex-vivo isolated heart model has been extensively used to study cardiac function for many years. However, electrical and mechanical function are often studied separately - despite growing proof of a complex electro-mechanical interaction in cardiac physiology and pathology. Therefore, we developed an isolated mouse heart perfusion system that allows simultaneous recording of electrical and mechanical function. Methods Isolated mouse hearts were mounted on a Langendorff setup and electrical function was assessed via a pseudo-ECG and an octapolar catheter inserted in the right atrium and ventricle. Mechanical function was simultaneously assessed via a balloon inserted into the left ventricle coupled with pressure determination. Hearts were then submitted to an ischemia-reperfusion protocol. Results At baseline, heart rate, PR and QT intervals, intra-atrial and intra-ventricular conduction times, as well as ventricular effective refractory period, could be measured as parameters of cardiac electrical function. Left ventricular developed pressure (DP), left ventricular work (DP-heart rate product) and maximal velocities of contraction and relaxation were used to assess cardiac mechanical function. Cardiac arrhythmias were observed with episodes of bigeminy during which DP was significantly increased compared to that of sinus rhythm episodes. In addition, the extrasystole-triggered contraction was only 50% of that of sinus rhythm, recapitulating the “pulse deficit” phenomenon observed in bigeminy patients. After ischemia, the mechanical function significantly decreased and slowly recovered during reperfusion while most of the electrical parameters remained unchanged. Finally, the same electro-mechanical interaction during episodes of bigeminy at baseline was observed during reperfusion. Conclusion Our modified Langendorff setup allows simultaneous recording of electrical and mechanical function on a beat-to-beat scale and can be used to study electro-mechanical interaction in isolated mouse hearts." @default.
• W4386811706 created "2023-09-18" @default.
• W4386811706 creator A5014344319 @default.
• W4386811706 creator A5025220354 @default.
• W4386811706 creator A5033062623 @default.
• W4386811706 creator A5046718631 @default.
• W4386811706 creator A5049133102 @default.
• W4386811706 creator A5049186738 @default.
• W4386811706 creator A5063726355 @default.
• W4386811706 creator A5064876009 @default.
• W4386811706 creator A5068295003 @default.
• W4386811706 creator A5072551161 @default.
• W4386811706 creator A5074206901 @default.
• W4386811706 creator A5082369212 @default.
• W4386811706 creator A5092890848 @default.
• W4386811706 date "2023-09-17" @default.
• W4386811706 modified "2023-10-03" @default.
• W4386811706 title "Simultaneous assessment of mechanical and electrical function in Langendorff-perfused ex-vivo mouse heart" @default.
• W4386811706 cites W1535877177 @default.
• W4386811706 cites W1934994215 @default.
• W4386811706 cites W1970897517 @default.
• W4386811706 cites W1999356573 @default.
• W4386811706 cites W2002459297 @default.
• W4386811706 cites W2003203834 @default.
• W4386811706 cites W2003861577 @default.
• W4386811706 cites W2006364565 @default.
• W4386811706 cites W2020859911 @default.
• W4386811706 cites W2021400734 @default.
• W4386811706 cites W2043355876 @default.
• W4386811706 cites W2047563687 @default.
• W4386811706 cites W2051711363 @default.
• W4386811706 cites W2104830583 @default.
• W4386811706 cites W2105140175 @default.
• W4386811706 cites W2117958259 @default.
• W4386811706 cites W2118727366 @default.
• W4386811706 cites W2137442910 @default.
• W4386811706 cites W2138621771 @default.
• W4386811706 cites W2155592501 @default.
• W4386811706 cites W2157109878 @default.
• W4386811706 cites W2168924687 @default.
• W4386811706 cites W2169582078 @default.
• W4386811706 cites W2170027042 @default.
• W4386811706 cites W2345850148 @default.
• W4386811706 cites W2443741178 @default.
• W4386811706 cites W2746845966 @default.
• W4386811706 cites W2886663158 @default.
• W4386811706 cites W2972789149 @default.
• W4386811706 cites W2995889897 @default.
• W4386811706 cites W3021486524 @default.
• W4386811706 cites W3127581834 @default.
• W4386811706 cites W3149416277 @default.
• W4386811706 cites W4210242902 @default.
• W4386811706 cites W4214866542 @default.
• W4386811706 cites W4238447226 @default.
• W4386811706 cites W4304614932 @default.
• W4386811706 doi "https://doi.org/10.1101/2023.09.15.557526" @default.
• W4386811706 hasPublicationYear "2023" @default.
• W4386811706 type Work @default.
• W4386811706 citedByCount "0" @default.
• W4386811706 crossrefType "posted-content" @default.
• W4386811706 hasAuthorship W4386811706A5014344319 @default.
• W4386811706 hasAuthorship W4386811706A5025220354 @default.
• W4386811706 hasAuthorship W4386811706A5033062623 @default.
• W4386811706 hasAuthorship W4386811706A5046718631 @default.
• W4386811706 hasAuthorship W4386811706A5049133102 @default.
• W4386811706 hasAuthorship W4386811706A5049186738 @default.
• W4386811706 hasAuthorship W4386811706A5063726355 @default.
• W4386811706 hasAuthorship W4386811706A5064876009 @default.
• W4386811706 hasAuthorship W4386811706A5068295003 @default.
• W4386811706 hasAuthorship W4386811706A5072551161 @default.
• W4386811706 hasAuthorship W4386811706A5074206901 @default.
• W4386811706 hasAuthorship W4386811706A5082369212 @default.
• W4386811706 hasAuthorship W4386811706A5092890848 @default.
• W4386811706 hasBestOaLocation W43868117061 @default.
• W4386811706 hasConcept C111566952 @default.
• W4386811706 hasConcept C126322002 @default.
• W4386811706 hasConcept C150903083 @default.
• W4386811706 hasConcept C153430590 @default.
• W4386811706 hasConcept C164705383 @default.
• W4386811706 hasConcept C207001950 @default.
• W4386811706 hasConcept C26291073 @default.
• W4386811706 hasConcept C2775914520 @default.
• W4386811706 hasConcept C2776331378 @default.
• W4386811706 hasConcept C2778198053 @default.
• W4386811706 hasConcept C2778921608 @default.
• W4386811706 hasConcept C2779161974 @default.
• W4386811706 hasConcept C42219234 @default.
• W4386811706 hasConcept C71924100 @default.
• W4386811706 hasConcept C86803240 @default.
• W4386811706 hasConceptScore W4386811706C111566952 @default.
• W4386811706 hasConceptScore W4386811706C126322002 @default.
• W4386811706 hasConceptScore W4386811706C150903083 @default.
• W4386811706 hasConceptScore W4386811706C153430590 @default.
• W4386811706 hasConceptScore W4386811706C164705383 @default.
• W4386811706 hasConceptScore W4386811706C207001950 @default.
• W4386811706 hasConceptScore W4386811706C26291073 @default.
• W4386811706 hasConceptScore W4386811706C2775914520 @default.
• W4386811706 hasConceptScore W4386811706C2776331378 @default.
• W4386811706 hasConceptScore W4386811706C2778198053 @default.
• W4386811706 hasConceptScore W4386811706C2778921608 @default.

• next