Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386811897> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W4386811897 abstract "Abstract Efficient utilization of large-scale biobank data is crucial for inferring the genetic basis of disease and predicting health outcomes from the DNA. Yet we lack accurate methods that scale to data where electronic health records are linked to whole genome sequence information. To address this issue, we develop a new algorithmic paradigm based on Approximate Message Passing (AMP), which is specifically tailored for genomic prediction and association testing. Our method yields comparable out-of-sample prediction accuracy to the state of the art on UK Biobank traits, whilst dramatically improving computational complexity, with a 10x-speed up in the run time. In addition, AMP theory provides a joint association testing framework, which outperforms the commonly used REGENIE method, in a third of the compute time. This first, truly large-scale application of the AMP framework lays the foundations for a far wider range of statistical analyses for hundreds of millions of variables measured on millions of people." @default.
- W4386811897 created "2023-09-18" @default.
- W4386811897 creator A5027175251 @default.
- W4386811897 creator A5061114394 @default.
- W4386811897 creator A5092890873 @default.
- W4386811897 date "2023-09-17" @default.
- W4386811897 modified "2023-09-28" @default.
- W4386811897 title "Light-speed Inference of Genetic Effects via Approximate Message Passing" @default.
- W4386811897 cites W1539800233 @default.
- W4386811897 cites W1966775465 @default.
- W4386811897 cites W2082029531 @default.
- W4386811897 cites W2166500259 @default.
- W4386811897 cites W2166670884 @default.
- W4386811897 cites W2326225147 @default.
- W4386811897 cites W2891437428 @default.
- W4386811897 cites W2918745211 @default.
- W4386811897 cites W2945463326 @default.
- W4386811897 cites W2962760202 @default.
- W4386811897 cites W2963060833 @default.
- W4386811897 cites W2963676935 @default.
- W4386811897 cites W2994642650 @default.
- W4386811897 cites W3098848552 @default.
- W4386811897 cites W3162800482 @default.
- W4386811897 cites W3212584598 @default.
- W4386811897 cites W4206290801 @default.
- W4386811897 cites W4210727822 @default.
- W4386811897 cites W4288694737 @default.
- W4386811897 cites W4317934540 @default.
- W4386811897 cites W4384662385 @default.
- W4386811897 doi "https://doi.org/10.1101/2023.09.14.557703" @default.
- W4386811897 hasPublicationYear "2023" @default.
- W4386811897 type Work @default.
- W4386811897 citedByCount "0" @default.
- W4386811897 crossrefType "posted-content" @default.
- W4386811897 hasAuthorship W4386811897A5027175251 @default.
- W4386811897 hasAuthorship W4386811897A5061114394 @default.
- W4386811897 hasAuthorship W4386811897A5092890873 @default.
- W4386811897 hasBestOaLocation W43868118971 @default.
- W4386811897 hasConcept C116567970 @default.
- W4386811897 hasConcept C119857082 @default.
- W4386811897 hasConcept C120314980 @default.
- W4386811897 hasConcept C121332964 @default.
- W4386811897 hasConcept C124101348 @default.
- W4386811897 hasConcept C127413603 @default.
- W4386811897 hasConcept C146978453 @default.
- W4386811897 hasConcept C154945302 @default.
- W4386811897 hasConcept C204323151 @default.
- W4386811897 hasConcept C2522767166 @default.
- W4386811897 hasConcept C2776214188 @default.
- W4386811897 hasConcept C2778755073 @default.
- W4386811897 hasConcept C41008148 @default.
- W4386811897 hasConcept C60644358 @default.
- W4386811897 hasConcept C62520636 @default.
- W4386811897 hasConcept C854659 @default.
- W4386811897 hasConcept C86803240 @default.
- W4386811897 hasConceptScore W4386811897C116567970 @default.
- W4386811897 hasConceptScore W4386811897C119857082 @default.
- W4386811897 hasConceptScore W4386811897C120314980 @default.
- W4386811897 hasConceptScore W4386811897C121332964 @default.
- W4386811897 hasConceptScore W4386811897C124101348 @default.
- W4386811897 hasConceptScore W4386811897C127413603 @default.
- W4386811897 hasConceptScore W4386811897C146978453 @default.
- W4386811897 hasConceptScore W4386811897C154945302 @default.
- W4386811897 hasConceptScore W4386811897C204323151 @default.
- W4386811897 hasConceptScore W4386811897C2522767166 @default.
- W4386811897 hasConceptScore W4386811897C2776214188 @default.
- W4386811897 hasConceptScore W4386811897C2778755073 @default.
- W4386811897 hasConceptScore W4386811897C41008148 @default.
- W4386811897 hasConceptScore W4386811897C60644358 @default.
- W4386811897 hasConceptScore W4386811897C62520636 @default.
- W4386811897 hasConceptScore W4386811897C854659 @default.
- W4386811897 hasConceptScore W4386811897C86803240 @default.
- W4386811897 hasLocation W43868118971 @default.
- W4386811897 hasOpenAccess W4386811897 @default.
- W4386811897 hasPrimaryLocation W43868118971 @default.
- W4386811897 hasRelatedWork W1495535967 @default.
- W4386811897 hasRelatedWork W1509819746 @default.
- W4386811897 hasRelatedWork W1834449470 @default.
- W4386811897 hasRelatedWork W2098337892 @default.
- W4386811897 hasRelatedWork W2281761054 @default.
- W4386811897 hasRelatedWork W2368564840 @default.
- W4386811897 hasRelatedWork W2610473248 @default.
- W4386811897 hasRelatedWork W2961085424 @default.
- W4386811897 hasRelatedWork W4306674287 @default.
- W4386811897 hasRelatedWork W4327676743 @default.
- W4386811897 isParatext "false" @default.
- W4386811897 isRetracted "false" @default.
- W4386811897 workType "article" @default.