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- W4386812556 abstract "Improving clinical practice in disease-modifying therapies is an important strategy in coping with the progressive course of Alzheimer's Disease (AD). This study aimed to develop DO and VB12-loaded nanofibers (DO/VB12-loaded NFs) as a transdermal drug delivery system, examine physicochemical properties, and evaluate the in vitro anti-Alzheimer's activity. DO/VB12-loaded NFs were produced with enhanced properties and a smooth structure without bead formation by the pressured gyration method. The drugs showed rapid release from DO/VB12-loaded NFs on the first day followed by sustained release for 14 days, indicating their suitability for transdermal application. Furthermore, the anti-Alzheimer's potential of DO/VB12-loaded NFs was investigated in a wide range using the functional ability of mitochondria (MTT) and viability analysis in amyloid-β (Aβ)-induced SH-SY5Y cells. The in vitro AD activity of DO/VB12-loaded NFs has been demonstrated as they are not cellular cytotoxic, promote viability in SH-SY5Y cells against Aβ1-42-induced neurotoxicity, and decrease gene expressions of APP and BACE-1, increase ADAM-10. In addition, cell morphology was visualized by confocal microscopy after treatment with DO/VB12-loaded NFs. Overall, those data showed that the designed NFs are a promising alternative to deliver DO and VB12 transdermally for the treatment of AD." @default.
- W4386812556 created "2023-09-18" @default.
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- W4386812556 date "2023-11-01" @default.
- W4386812556 modified "2023-10-10" @default.
- W4386812556 title "A novel high-efficiency transdermal patches for combinational therapy of Alzheimer's disease: Donepezil/vitamin B12-Loaded nanofibers" @default.
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- W4386812556 doi "https://doi.org/10.1016/j.jddst.2023.104963" @default.
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