Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386814030> ?p ?o ?g. }
- W4386814030 endingPage "115810" @default.
- W4386814030 startingPage "115810" @default.
- W4386814030 abstract "Pancreatic ductal adenocarcinoma (PDAC) remains one of the most devastating diseases; it has a considerably poor prognosis and may become the second most lethal malignancy in the next 10 years. Chemotherapeutic resistance is common in PDAC; thus, it is necessary to exploit effective alternative drugs. In recent years, traditional folk medicines and their extracts have shown great potential in cancer treatment. The seed of Lagenaria siceraria (Molina) Standl. is a traditional medicine in Asia. Because of its analgesic effects and ability to reduce swelling, it is often used as an adjuvant treatment for abdominal tumors. Cucurbitacin compounds are extracts abundant in Lagenaria siceraria (Molina) Standl. Here, we found that cucurbitacin C (CuC), a member of the cucurbitacin family, has apparent anti-PDAC therapeutic properties. CuC decreased the viability and suppressed the proliferation of PDAC cells in a time- and dose-dependent manner. Further studies revealed that CuC inhibited cell migration and invasion by inhibiting epithelial-mesenchymal transition (EMT). In addition, G2/M arrest was induced, and the apoptotic pathway was activated. Transcriptomic and bioinformatic analyses showed that CuC inhibited the cGMP-PKG-VASP axis, increasing the content of cGMP to restore tumor characteristics. The antitumor activity of CuC in vivo was verified through animal experiments, and no obvious side effects were observed. Overall, our study indicates a candidate therapeutic compound for PDAC that is worthy of further development." @default.
- W4386814030 created "2023-09-18" @default.
- W4386814030 creator A5027279764 @default.
- W4386814030 creator A5032449956 @default.
- W4386814030 creator A5045203904 @default.
- W4386814030 creator A5048115276 @default.
- W4386814030 creator A5053348244 @default.
- W4386814030 creator A5057055806 @default.
- W4386814030 creator A5072836714 @default.
- W4386814030 creator A5081313743 @default.
- W4386814030 creator A5086491608 @default.
- W4386814030 date "2023-11-01" @default.
- W4386814030 modified "2023-09-29" @default.
- W4386814030 title "Cucurbitacin C suppresses the progression of pancreatic ductal adenocarcinoma via inhibition of the cGMP-PKG-VASP axis" @default.
- W4386814030 cites W1946106397 @default.
- W4386814030 cites W1987313243 @default.
- W4386814030 cites W2025510934 @default.
- W4386814030 cites W2117692326 @default.
- W4386814030 cites W2145181332 @default.
- W4386814030 cites W2151253787 @default.
- W4386814030 cites W2160234311 @default.
- W4386814030 cites W2165480504 @default.
- W4386814030 cites W2530854269 @default.
- W4386814030 cites W2802932138 @default.
- W4386814030 cites W2905609962 @default.
- W4386814030 cites W2909710916 @default.
- W4386814030 cites W2977003665 @default.
- W4386814030 cites W3007279522 @default.
- W4386814030 cites W3043202257 @default.
- W4386814030 cites W3048840742 @default.
- W4386814030 cites W3081622691 @default.
- W4386814030 cites W3102777791 @default.
- W4386814030 cites W3103950135 @default.
- W4386814030 cites W3173746096 @default.
- W4386814030 cites W3197559541 @default.
- W4386814030 cites W3213940756 @default.
- W4386814030 cites W4200354421 @default.
- W4386814030 cites W4206841660 @default.
- W4386814030 cites W4211208840 @default.
- W4386814030 cites W4211253487 @default.
- W4386814030 cites W4213018448 @default.
- W4386814030 cites W4213436177 @default.
- W4386814030 cites W4293516795 @default.
- W4386814030 cites W4327559537 @default.
- W4386814030 cites W4367043529 @default.
- W4386814030 cites W4379768348 @default.
- W4386814030 doi "https://doi.org/10.1016/j.bcp.2023.115810" @default.
- W4386814030 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37717690" @default.
- W4386814030 hasPublicationYear "2023" @default.
- W4386814030 type Work @default.
- W4386814030 citedByCount "0" @default.
- W4386814030 crossrefType "journal-article" @default.
- W4386814030 hasAuthorship W4386814030A5027279764 @default.
- W4386814030 hasAuthorship W4386814030A5032449956 @default.
- W4386814030 hasAuthorship W4386814030A5045203904 @default.
- W4386814030 hasAuthorship W4386814030A5048115276 @default.
- W4386814030 hasAuthorship W4386814030A5053348244 @default.
- W4386814030 hasAuthorship W4386814030A5057055806 @default.
- W4386814030 hasAuthorship W4386814030A5072836714 @default.
- W4386814030 hasAuthorship W4386814030A5081313743 @default.
- W4386814030 hasAuthorship W4386814030A5086491608 @default.
- W4386814030 hasConcept C121608353 @default.
- W4386814030 hasConcept C126322002 @default.
- W4386814030 hasConcept C150903083 @default.
- W4386814030 hasConcept C185592680 @default.
- W4386814030 hasConcept C190283241 @default.
- W4386814030 hasConcept C207001950 @default.
- W4386814030 hasConcept C2779399171 @default.
- W4386814030 hasConcept C2780210213 @default.
- W4386814030 hasConcept C502942594 @default.
- W4386814030 hasConcept C55493867 @default.
- W4386814030 hasConcept C71924100 @default.
- W4386814030 hasConcept C86803240 @default.
- W4386814030 hasConcept C98274493 @default.
- W4386814030 hasConceptScore W4386814030C121608353 @default.
- W4386814030 hasConceptScore W4386814030C126322002 @default.
- W4386814030 hasConceptScore W4386814030C150903083 @default.
- W4386814030 hasConceptScore W4386814030C185592680 @default.
- W4386814030 hasConceptScore W4386814030C190283241 @default.
- W4386814030 hasConceptScore W4386814030C207001950 @default.
- W4386814030 hasConceptScore W4386814030C2779399171 @default.
- W4386814030 hasConceptScore W4386814030C2780210213 @default.
- W4386814030 hasConceptScore W4386814030C502942594 @default.
- W4386814030 hasConceptScore W4386814030C55493867 @default.
- W4386814030 hasConceptScore W4386814030C71924100 @default.
- W4386814030 hasConceptScore W4386814030C86803240 @default.
- W4386814030 hasConceptScore W4386814030C98274493 @default.
- W4386814030 hasLocation W43868140301 @default.
- W4386814030 hasLocation W43868140302 @default.
- W4386814030 hasOpenAccess W4386814030 @default.
- W4386814030 hasPrimaryLocation W43868140301 @default.
- W4386814030 hasRelatedWork W2007315078 @default.
- W4386814030 hasRelatedWork W2043890160 @default.
- W4386814030 hasRelatedWork W2050306700 @default.
- W4386814030 hasRelatedWork W2367700600 @default.
- W4386814030 hasRelatedWork W2382765128 @default.
- W4386814030 hasRelatedWork W2414946262 @default.
- W4386814030 hasRelatedWork W2748952813 @default.