Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386814581> ?p ?o ?g. }
- W4386814581 endingPage "1306" @default.
- W4386814581 startingPage "1306" @default.
- W4386814581 abstract "Neurodegeneration, characterized by the progressive deterioration of neurons and glial cells, is a feature of Alzheimer's disease (AD). The present study aims to demonstrate that the onset and early progression of neurodegenerative processes in transgenic mice models of AD can be delayed by a cocktail of neurotrophic factors and derived peptides named Nosustrophine, a nootropic supplement made by a peptide complex extracted from the young porcine brain, ensuring neuroprotection and improving neuro-functional recovery. Experimental 3xTg-APP/Bin1/COPS5 transgenic mice models of AD were treated with Nosustrophine at two different early ages, and their neuropathological hallmark and behavior response were analyzed. Results showed that Nosustrophine increased the activity of the immune system and reduced pathological changes in the hippocampus and cortex by halting the development of amyloid plaques, mainly seen in mice of 3-4 months of age, indicating that its effect is more preventive than therapeutic. Taken together, the results indicate the potent neuroprotective activity of Nosustrophine and its stimulating effects on neuronal plasticity. This study shows for the first time an effective therapy using nootropic supplements against degenerative diseases, although further investigation is needed to understand their molecular pathways." @default.
- W4386814581 created "2023-09-18" @default.
- W4386814581 creator A5004538565 @default.
- W4386814581 creator A5013697272 @default.
- W4386814581 creator A5022359956 @default.
- W4386814581 creator A5073941282 @default.
- W4386814581 creator A5091401644 @default.
- W4386814581 date "2023-09-15" @default.
- W4386814581 modified "2023-10-17" @default.
- W4386814581 title "Neuroprotective Effect of Nosustrophine in a 3xTg Mouse Model of Alzheimer’s Disease" @default.
- W4386814581 cites W1555679702 @default.
- W4386814581 cites W1773800241 @default.
- W4386814581 cites W1961744561 @default.
- W4386814581 cites W1980508446 @default.
- W4386814581 cites W1987077773 @default.
- W4386814581 cites W2001459428 @default.
- W4386814581 cites W2001856136 @default.
- W4386814581 cites W2007960442 @default.
- W4386814581 cites W2014769762 @default.
- W4386814581 cites W2031701023 @default.
- W4386814581 cites W2033725459 @default.
- W4386814581 cites W2033950872 @default.
- W4386814581 cites W2037335353 @default.
- W4386814581 cites W2060627587 @default.
- W4386814581 cites W2062133591 @default.
- W4386814581 cites W207124143 @default.
- W4386814581 cites W2072195566 @default.
- W4386814581 cites W2112233227 @default.
- W4386814581 cites W2113198638 @default.
- W4386814581 cites W2116481151 @default.
- W4386814581 cites W2136484866 @default.
- W4386814581 cites W2158042711 @default.
- W4386814581 cites W2164207060 @default.
- W4386814581 cites W2170544103 @default.
- W4386814581 cites W2192674214 @default.
- W4386814581 cites W2266543467 @default.
- W4386814581 cites W2413736368 @default.
- W4386814581 cites W2522303657 @default.
- W4386814581 cites W2557883205 @default.
- W4386814581 cites W2765685564 @default.
- W4386814581 cites W2794968960 @default.
- W4386814581 cites W2796681594 @default.
- W4386814581 cites W2806595350 @default.
- W4386814581 cites W2904588387 @default.
- W4386814581 cites W3000061404 @default.
- W4386814581 cites W3045373701 @default.
- W4386814581 cites W3158873872 @default.
- W4386814581 cites W4213443280 @default.
- W4386814581 cites W4221121956 @default.
- W4386814581 cites W4309008735 @default.
- W4386814581 cites W4319773498 @default.
- W4386814581 cites W4385577760 @default.
- W4386814581 doi "https://doi.org/10.3390/ph16091306" @default.
- W4386814581 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37765114" @default.
- W4386814581 hasPublicationYear "2023" @default.
- W4386814581 type Work @default.
- W4386814581 citedByCount "0" @default.
- W4386814581 crossrefType "journal-article" @default.
- W4386814581 hasAuthorship W4386814581A5004538565 @default.
- W4386814581 hasAuthorship W4386814581A5013697272 @default.
- W4386814581 hasAuthorship W4386814581A5022359956 @default.
- W4386814581 hasAuthorship W4386814581A5073941282 @default.
- W4386814581 hasAuthorship W4386814581A5091401644 @default.
- W4386814581 hasBestOaLocation W43868145811 @default.
- W4386814581 hasConcept C102230213 @default.
- W4386814581 hasConcept C104317684 @default.
- W4386814581 hasConcept C126322002 @default.
- W4386814581 hasConcept C141035611 @default.
- W4386814581 hasConcept C142724271 @default.
- W4386814581 hasConcept C160539049 @default.
- W4386814581 hasConcept C169760540 @default.
- W4386814581 hasConcept C170493617 @default.
- W4386814581 hasConcept C25498285 @default.
- W4386814581 hasConcept C2776239663 @default.
- W4386814581 hasConcept C2776925932 @default.
- W4386814581 hasConcept C2779134260 @default.
- W4386814581 hasConcept C2781161787 @default.
- W4386814581 hasConcept C47611674 @default.
- W4386814581 hasConcept C55493867 @default.
- W4386814581 hasConcept C71924100 @default.
- W4386814581 hasConcept C86803240 @default.
- W4386814581 hasConcept C92020748 @default.
- W4386814581 hasConcept C98274493 @default.
- W4386814581 hasConceptScore W4386814581C102230213 @default.
- W4386814581 hasConceptScore W4386814581C104317684 @default.
- W4386814581 hasConceptScore W4386814581C126322002 @default.
- W4386814581 hasConceptScore W4386814581C141035611 @default.
- W4386814581 hasConceptScore W4386814581C142724271 @default.
- W4386814581 hasConceptScore W4386814581C160539049 @default.
- W4386814581 hasConceptScore W4386814581C169760540 @default.
- W4386814581 hasConceptScore W4386814581C170493617 @default.
- W4386814581 hasConceptScore W4386814581C25498285 @default.
- W4386814581 hasConceptScore W4386814581C2776239663 @default.
- W4386814581 hasConceptScore W4386814581C2776925932 @default.
- W4386814581 hasConceptScore W4386814581C2779134260 @default.
- W4386814581 hasConceptScore W4386814581C2781161787 @default.
- W4386814581 hasConceptScore W4386814581C47611674 @default.
- W4386814581 hasConceptScore W4386814581C55493867 @default.