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- W4386814824 endingPage "14179" @default.
- W4386814824 startingPage "14179" @default.
- W4386814824 abstract "The fibrinolytic system is a key player in keeping the haemostatic balance, and changes in fibrinolytic capacity can lead to both bleeding-related and thrombosis-related disorders. Our knowledge of the fibrinolytic system has expanded immensely during the last 75 years. From the first successful use of thrombolysis in myocardial infarction in the 1960s, thrombolytic therapy is now widely implemented and has reformed treatment in vascular medicine, especially ischemic stroke, while antifibrinolytic agents are used routinely in the prevention and treatment of major bleeding worldwide. Despite this, this research field still holds unanswered questions. Accurate and timely laboratory diagnosis of disturbed fibrinolysis in the clinical setting remains a challenge. Furthermore, despite growing evidence that hypofibrinolysis plays a central role in, e.g., sepsis-related coagulopathy, coronary artery disease, and venous thromboembolism, there is currently no approved treatment of hypofibrinolysis in these settings. The present review provides an overview of the fibrinolytic system and history of its discovery; measurement methods; clinical relevance of the fibrinolytic system in diagnosis and treatment; and points to future directions for research." @default.
- W4386814824 created "2023-09-18" @default.
- W4386814824 creator A5015612746 @default.
- W4386814824 creator A5021080778 @default.
- W4386814824 date "2023-09-16" @default.
- W4386814824 modified "2023-10-04" @default.
- W4386814824 title "The Fibrinolytic System and Its Measurement: History, Current Uses and Future Directions for Diagnosis and Treatment" @default.
- W4386814824 cites W146872388 @default.
- W4386814824 cites W1489080798 @default.
- W4386814824 cites W1526544241 @default.
- W4386814824 cites W1569358024 @default.
- W4386814824 cites W1599132736 @default.
- W4386814824 cites W1611413521 @default.
- W4386814824 cites W1618760884 @default.
- W4386814824 cites W1769450009 @default.
- W4386814824 cites W1853156458 @default.
- W4386814824 cites W1892118861 @default.
- W4386814824 cites W1897147442 @default.
- W4386814824 cites W1898928487 @default.
- W4386814824 cites W1958899625 @default.
- W4386814824 cites W1964933826 @default.
- W4386814824 cites W1965865837 @default.
- W4386814824 cites W1969497394 @default.
- W4386814824 cites W1976100378 @default.
- W4386814824 cites W1986778170 @default.
- W4386814824 cites W1994606618 @default.
- W4386814824 cites W2000479898 @default.
- W4386814824 cites W2000502450 @default.
- W4386814824 cites W2003364720 @default.
- W4386814824 cites W2007725602 @default.
- W4386814824 cites W2018030670 @default.
- W4386814824 cites W2022031418 @default.
- W4386814824 cites W2028418523 @default.
- W4386814824 cites W2028816956 @default.
- W4386814824 cites W2029599595 @default.
- W4386814824 cites W2032242846 @default.
- W4386814824 cites W2037994872 @default.
- W4386814824 cites W2039057366 @default.
- W4386814824 cites W2041467026 @default.
- W4386814824 cites W2042811719 @default.
- W4386814824 cites W2047350508 @default.
- W4386814824 cites W2057007282 @default.
- W4386814824 cites W2059040088 @default.
- W4386814824 cites W2065459298 @default.
- W4386814824 cites W2066822578 @default.
- W4386814824 cites W2075182040 @default.
- W4386814824 cites W2075420392 @default.
- W4386814824 cites W2088688755 @default.
- W4386814824 cites W2092707717 @default.
- W4386814824 cites W2093338681 @default.
- W4386814824 cites W2096915260 @default.
- W4386814824 cites W2100118997 @default.
- W4386814824 cites W210528726 @default.
- W4386814824 cites W2110828958 @default.
- W4386814824 cites W2113844812 @default.
- W4386814824 cites W2114180453 @default.
- W4386814824 cites W2120949451 @default.
- W4386814824 cites W2124107576 @default.
- W4386814824 cites W2128343978 @default.
- W4386814824 cites W2128916601 @default.
- W4386814824 cites W2137010719 @default.
- W4386814824 cites W2144895900 @default.
- W4386814824 cites W2148373446 @default.
- W4386814824 cites W2152143425 @default.
- W4386814824 cites W2156091573 @default.
- W4386814824 cites W2156686805 @default.
- W4386814824 cites W2159743452 @default.
- W4386814824 cites W2162249417 @default.
- W4386814824 cites W2168570794 @default.
- W4386814824 cites W2172965897 @default.
- W4386814824 cites W2178434425 @default.
- W4386814824 cites W2230122464 @default.
- W4386814824 cites W2233281615 @default.
- W4386814824 cites W2274749402 @default.
- W4386814824 cites W2280404143 @default.
- W4386814824 cites W2327802212 @default.
- W4386814824 cites W2338879757 @default.
- W4386814824 cites W234419484 @default.
- W4386814824 cites W2346951597 @default.
- W4386814824 cites W2395939747 @default.
- W4386814824 cites W2401370288 @default.
- W4386814824 cites W2409226962 @default.
- W4386814824 cites W2413186508 @default.
- W4386814824 cites W2485602029 @default.
- W4386814824 cites W2553300030 @default.
- W4386814824 cites W2565279855 @default.
- W4386814824 cites W2580821343 @default.
- W4386814824 cites W2607870311 @default.
- W4386814824 cites W2742981589 @default.
- W4386814824 cites W2747912680 @default.
- W4386814824 cites W2760821898 @default.
- W4386814824 cites W2776590467 @default.
- W4386814824 cites W2789512318 @default.
- W4386814824 cites W2793000938 @default.
- W4386814824 cites W2793931917 @default.
- W4386814824 cites W2796568037 @default.
- W4386814824 cites W2799403580 @default.
- W4386814824 cites W2800435417 @default.