Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386817557> ?p ?o ?g. }
- W4386817557 abstract "The unfolded protein response (UPR) is a cellular mechanism that protects cells during stress conditions in which there is an accumulation of misfolded proteins in the endoplasmic reticulum (ER). UPR activates three signaling pathways that function to alleviate stress conditions and promote cellular homeostasis and cell survival. During unmitigated stress conditions, however, UPR activation signaling changes to promote cell death through apoptosis. Interestingly, cancer cells take advantage of this pathway to facilitate survival and avoid apoptosis even during prolonged cell stress conditions. Here, we discuss different signaling pathways associated with UPR and focus specifically on one of the ER signaling pathways activated during UPR, inositol-requiring enzyme 1α (IRE1). The rationale is that the IRE1 pathway is associated with cell fate decisions and recognized as a promising target for cancer therapeutics. Here we discuss IRE1 inhibitors and how they might prove to be an effective cancer therapeutic." @default.
- W4386817557 created "2023-09-19" @default.
- W4386817557 creator A5024006453 @default.
- W4386817557 creator A5036813232 @default.
- W4386817557 creator A5039708431 @default.
- W4386817557 creator A5084938933 @default.
- W4386817557 date "2023-09-18" @default.
- W4386817557 modified "2023-09-26" @default.
- W4386817557 title "Dual RNase activity of IRE1 as a target for anticancer therapies" @default.
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