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- W4386817683 abstract "B cell receptor (BCR) signaling is crucial for normal B cell development and adaptive immunity. In chronic lymphocytic leukemia (CLL), the malignant B cells display many features of normal mature B lymphocytes, including the expression of functional B cell receptors (BCR). Cross talk between CLL cells and the microenvironment in secondary lymphatic organs results in BCR signaling and BCR-driven proliferation of the CLL cells. This critical pathomechanism can be targeted by blocking BCR-related kinases (BTK, PI3K, SYK) using small molecule inhibitors. Among these targets, Bruton tyrosine kinase (BTK) inhibitors have the highest therapeutic efficacy; they effectively block leukemia cell proliferation and generally induce durable remissions in CLL patients, even in patients with high-risk disease. By disrupting tissue homing receptor (i.e. chemokine receptor and adhesion molecule) signaling, these kinase inhibitors also mobilize CLL cells from the lymphatic tissues into the peripheral blood, causing a transient redistribution lymphocytosis, thereby depriving CLL cells from nurturing factors within the tissue niches. The clinical success of the BTK inhibitors in CLL underscore the central importance of the BCR in CLL pathogenesis. Here, we review CLL pathogenesis with a focus on the role of the BCR and other microenvironment cues." @default.
- W4386817683 created "2023-09-19" @default.
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- W4386817683 date "2023-09-16" @default.
- W4386817683 modified "2023-10-12" @default.
- W4386817683 title "Chronic lymphocytic leukemia: disease biology" @default.
- W4386817683 doi "https://doi.org/10.1159/000533610" @default.
- W4386817683 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37717577" @default.
- W4386817683 hasPublicationYear "2023" @default.
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