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• W4386825725 endingPage "e3002305" @default.
• W4386825725 startingPage "e3002305" @default.
• W4386825725 abstract "Protein function can be modulated by phase transitions in their material properties, which can range from liquid- to solid-like; yet, the mechanisms that drive these transitions and whether they are important for physiology are still unknown. In the model plant Arabidopsis, we show that developmental robustness is reinforced by phase transitions of the plasma membrane-bound lipid-binding protein SEC14-like. Using imaging, genetics, and in vitro reconstitution experiments, we show that SEC14-like undergoes liquid-like phase separation in the root stem cells. Outside the stem cell niche, SEC14-like associates with the caspase-like protease separase and conserved microtubule motors at unique polar plasma membrane interfaces. In these interfaces, SEC14-like undergoes processing by separase, which promotes its liquid-to-solid transition. This transition is important for root development, as lines expressing an uncleavable SEC14-like variant or mutants of separase and associated microtubule motors show similar developmental phenotypes. Furthermore, the processed and solidified but not the liquid form of SEC14-like interacts with and regulates the polarity of the auxin efflux carrier PINFORMED2. This work demonstrates that robust development can involve liquid-to-solid transitions mediated by proteolysis at unique plasma membrane interfaces." @default.
• W4386825725 created "2023-09-19" @default.
• W4386825725 creator A5000186176 @default.
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• W4386825725 date "2023-09-18" @default.
• W4386825725 modified "2023-10-12" @default.
• W4386825725 title "SEC14-like condensate phase transitions at plasma membranes regulate root growth in Arabidopsis" @default.
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