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- W4386825835 endingPage "e1011672" @default.
- W4386825835 startingPage "e1011672" @default.
- W4386825835 abstract "Brucellosis, caused by facultative, intracellular Brucella spp., often results in chronic and/or lifelong infection. Therefore, Brucella must employ mechanisms to subvert adaptive immunity to cause chronic infection. B lymphocytes enhance susceptibility to infection with Brucella spp. though the mechanisms remain unclear. Here we investigated the role of antibody secretion, B cell receptor (BCR) specificity, and B cell antigen presentation on susceptibility to B. melitensis. We report that mice unable to secrete antibody do not display altered resistance to Brucella. However, animals with B cells that are unable to recognize Brucella through their BCR are resistant to infection. In addition, B cell MHCII expression enhances susceptibility to infection in a CD4+ T cell-dependent manner, and we found that follicular B cells are sufficient to inhibit CD4+ T cell-mediated immunity against Brucella. B cells promote development of T follicular helper (TFH) and T follicular regulatory (TFR) cells during Brucella infection. Inhibition of B cell and CD4+ T cell interaction via CD40L blockade enhances resistance to Brucella in a B cell dependent manner concomitant with suppression of TFH and TFR differentiation. Conversely, PD-1 blockade increases Brucella burdens in a B and CD4+ T cell dependent manner while augmenting T regulatory (TReg) and TFR responses. Intriguingly, TFR deficiency enhances resistance to Brucella via a B cell dependent, but antibody independent mechanism. Collectively, these results demonstrate B cells support TFR responses that promote susceptibility to Brucella infection independent of the antibody response." @default.
- W4386825835 created "2023-09-19" @default.
- W4386825835 creator A5009868743 @default.
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- W4386825835 creator A5024971127 @default.
- W4386825835 creator A5029347568 @default.
- W4386825835 creator A5050187189 @default.
- W4386825835 creator A5058000588 @default.
- W4386825835 creator A5066864788 @default.
- W4386825835 creator A5082144037 @default.
- W4386825835 date "2023-09-18" @default.
- W4386825835 modified "2023-10-17" @default.
- W4386825835 title "Interactions between B cells and T follicular regulatory cells enhance susceptibility to Brucella infection independent of the anti-Brucella humoral response" @default.
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