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• W4386826072 abstract "Abstract Chronic stress has become a predominant factor associated with a variety of psychiatric disorders, such as depression and anxiety, in both humans and animal models. Although multiple studies have looked at transcriptional changes after social defeat stress, these studies mostly focus on bulk tissues, which might dilute important molecular signatures of social interaction in activated cells. In this study, we employed the Arc-GFP mouse model in conjunction with chronic social defeat (CSD) to selectively isolate activated nuclei (AN) populations in the ventral hippocampus (vHIP) and prefrontal cortex (PFC) of resilient and susceptible animals. Nuclear RNA-seq of susceptible vs. resilient populations revealed distinct transcriptional profiles linked predominantly with neuronal and synaptic regulation mechanisms. In the vHIP, susceptible AN exhibited increased expression of genes related to cytoskeleton and synaptic organization while resilient AN showed upregulation of cell adhesion genes and differential expression of major glutamatergic subunits. In the PFC, susceptible mice exhibited upregulation of synaptotagmins, and immediate early genes (IEGs), suggesting a potentially over-amplified neuronal activity state. Our findings provide a novel view of stress-exposed neuronal activation and the molecular response mechanisms in stress-susceptible versus resilient animals, which may have important implications for understanding mental resilience." @default.
• W4386826072 created "2023-09-19" @default.
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• W4386826072 date "2023-09-18" @default.
• W4386826072 modified "2023-10-01" @default.
• W4386826072 title "Characterization of transcriptional profiles associated with stress-induced neuronal activation in Arc-GFP mice" @default.
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• W4386826072 doi "https://doi.org/10.21203/rs.3.rs-3273083/v1" @default.
• W4386826072 hasPublicationYear "2023" @default.
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