Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386826546> ?p ?o ?g. }
- W4386826546 endingPage "113347" @default.
- W4386826546 startingPage "113347" @default.
- W4386826546 abstract "Immunotherapy has ignited hope to cure paediatric solid tumours that resist traditional therapies. Among the most promising methods is adoptive cell therapy (ACT). Particularly, ACT using T cells equipped with chimeric antigen receptors (CARs) has moved into the spotlight in clinical studies. However, the efficacy of ACT is challenged by ACT-intrinsic factors, like lack of activation or T cell exhaustion, as well as immune evasion strategies of paediatric solid tumours, such as their highly immunosuppressive microenvironment. Novel strategies, including ACT using innate-like lymphocytes, innovative cell engineering techniques, and ACT combination therapies, are being developed and will be crucial to overcome these challenges. Here, we discuss the main classes of ACT for the treatment of paediatric extracranial solid tumours, reflect on the available preclinical and clinical evidence supporting promising strategies, and address the challenges that ACT is still facing. Ultimately, we highlight state-of-the-art developments and opportunities for new therapeutic options, which hold great potential for improving outcomes in this challenging patient population." @default.
- W4386826546 created "2023-09-19" @default.
- W4386826546 creator A5010046497 @default.
- W4386826546 creator A5012711850 @default.
- W4386826546 creator A5037521188 @default.
- W4386826546 creator A5057664255 @default.
- W4386826546 creator A5071314432 @default.
- W4386826546 creator A5092894294 @default.
- W4386826546 date "2023-11-01" @default.
- W4386826546 modified "2023-10-15" @default.
- W4386826546 title "Adoptive cell therapy in pediatric extracranial solid tumors: current approaches and future challenges" @default.
- W4386826546 cites W1165575940 @default.
- W4386826546 cites W1491394604 @default.
- W4386826546 cites W1513821330 @default.
- W4386826546 cites W1517456315 @default.
- W4386826546 cites W1574421689 @default.
- W4386826546 cites W1739527333 @default.
- W4386826546 cites W1748261727 @default.
- W4386826546 cites W1819122594 @default.
- W4386826546 cites W1852860294 @default.
- W4386826546 cites W1956825767 @default.
- W4386826546 cites W1965411116 @default.
- W4386826546 cites W1967445526 @default.
- W4386826546 cites W1973213475 @default.
- W4386826546 cites W1974108679 @default.
- W4386826546 cites W1975582036 @default.
- W4386826546 cites W1978757502 @default.
- W4386826546 cites W1990075911 @default.
- W4386826546 cites W1993506079 @default.
- W4386826546 cites W1994269871 @default.
- W4386826546 cites W1999843922 @default.
- W4386826546 cites W2001005805 @default.
- W4386826546 cites W2005354199 @default.
- W4386826546 cites W2011458181 @default.
- W4386826546 cites W2013255473 @default.
- W4386826546 cites W2014651277 @default.
- W4386826546 cites W2014998449 @default.
- W4386826546 cites W2017101609 @default.
- W4386826546 cites W2025141198 @default.
- W4386826546 cites W2027414351 @default.
- W4386826546 cites W2027863358 @default.
- W4386826546 cites W2028460943 @default.
- W4386826546 cites W2034769339 @default.
- W4386826546 cites W2036188114 @default.
- W4386826546 cites W2036970197 @default.
- W4386826546 cites W2037633167 @default.
- W4386826546 cites W2042174530 @default.
- W4386826546 cites W2044311205 @default.
- W4386826546 cites W2045522616 @default.
- W4386826546 cites W2048752843 @default.
- W4386826546 cites W2050698267 @default.
- W4386826546 cites W2063669319 @default.
- W4386826546 cites W2064510700 @default.
- W4386826546 cites W2066186103 @default.
- W4386826546 cites W2067224686 @default.
- W4386826546 cites W2067431214 @default.
- W4386826546 cites W2068890283 @default.
- W4386826546 cites W2070369806 @default.
- W4386826546 cites W2070748533 @default.
- W4386826546 cites W2071825091 @default.
- W4386826546 cites W2073573249 @default.
- W4386826546 cites W2073898672 @default.
- W4386826546 cites W2077971102 @default.
- W4386826546 cites W2081513802 @default.
- W4386826546 cites W2081734471 @default.
- W4386826546 cites W2085478834 @default.
- W4386826546 cites W2087055812 @default.
- W4386826546 cites W2093914368 @default.
- W4386826546 cites W2096728388 @default.
- W4386826546 cites W2096932117 @default.
- W4386826546 cites W2100234690 @default.
- W4386826546 cites W2102470992 @default.
- W4386826546 cites W2106263807 @default.
- W4386826546 cites W2112660458 @default.
- W4386826546 cites W2118763033 @default.
- W4386826546 cites W2119199226 @default.
- W4386826546 cites W2121374455 @default.
- W4386826546 cites W2121479816 @default.
- W4386826546 cites W2125028197 @default.
- W4386826546 cites W2129617805 @default.
- W4386826546 cites W2130465135 @default.
- W4386826546 cites W2131609628 @default.
- W4386826546 cites W2134257413 @default.
- W4386826546 cites W2135265711 @default.
- W4386826546 cites W2139710737 @default.
- W4386826546 cites W2144796561 @default.
- W4386826546 cites W2147068163 @default.
- W4386826546 cites W2147486937 @default.
- W4386826546 cites W2149079955 @default.
- W4386826546 cites W2151310238 @default.
- W4386826546 cites W2152041843 @default.
- W4386826546 cites W2153712501 @default.
- W4386826546 cites W2157003991 @default.
- W4386826546 cites W2157255884 @default.
- W4386826546 cites W2158514490 @default.
- W4386826546 cites W2159321255 @default.
- W4386826546 cites W2161307276 @default.
- W4386826546 cites W2164524832 @default.