Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386826570> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W4386826570 abstract "Abstract Bleeding and thrombosis are known as common complications of polycythemia for a long time. However, the role of coagulation system in erythropoiesis is unclear. Here, we discover that an anticoagulant protein tissue factor pathway inhibitor (TFPI) plays an essential role in erythropoiesis via the control of heme biosynthesis in central macrophages. TFPI levels are elevated in erythroblasts of human erythroblastic islands with JAK2 V617F mutation and hypoxia condition. Erythroid lineage-specific knockout TFPI results in impaired erythropoiesis through decreasing ferrochelatase expression and heme biosynthesis in central macrophages. Mechanistically, the TFPI interacts with thrombomodulin to promote the downstream ERK1/2-GATA1 signaling pathway to induce heme biosynthesis in central macrophages. Furthermore, TFPI blockade impairs human erythropoiesis in vitro , and normalizes the erythroid compartment in mice with polycythemia. These results show that erythroblast-derived TFPI plays an important role in the regulation of erythropoiesis and reveal an interplay between erythroblasts and central macrophages." @default.
- W4386826570 created "2023-09-19" @default.
- W4386826570 creator A5004829334 @default.
- W4386826570 creator A5015233033 @default.
- W4386826570 creator A5015693854 @default.
- W4386826570 creator A5021570938 @default.
- W4386826570 creator A5029782775 @default.
- W4386826570 creator A5031197115 @default.
- W4386826570 creator A5045648603 @default.
- W4386826570 creator A5046876292 @default.
- W4386826570 creator A5048072612 @default.
- W4386826570 creator A5048498264 @default.
- W4386826570 creator A5062788756 @default.
- W4386826570 creator A5066155047 @default.
- W4386826570 creator A5070486070 @default.
- W4386826570 creator A5080163279 @default.
- W4386826570 creator A5091013824 @default.
- W4386826570 date "2023-09-18" @default.
- W4386826570 modified "2023-09-26" @default.
- W4386826570 title "TFPI from Erythroblasts Drives Heme Production in Central Macrophages Promoting Erythropoiesis in Polycythemia" @default.
- W4386826570 doi "https://doi.org/10.21203/rs.3.rs-3202992/v1" @default.
- W4386826570 hasPublicationYear "2023" @default.
- W4386826570 type Work @default.
- W4386826570 citedByCount "0" @default.
- W4386826570 crossrefType "posted-content" @default.
- W4386826570 hasAuthorship W4386826570A5004829334 @default.
- W4386826570 hasAuthorship W4386826570A5015233033 @default.
- W4386826570 hasAuthorship W4386826570A5015693854 @default.
- W4386826570 hasAuthorship W4386826570A5021570938 @default.
- W4386826570 hasAuthorship W4386826570A5029782775 @default.
- W4386826570 hasAuthorship W4386826570A5031197115 @default.
- W4386826570 hasAuthorship W4386826570A5045648603 @default.
- W4386826570 hasAuthorship W4386826570A5046876292 @default.
- W4386826570 hasAuthorship W4386826570A5048072612 @default.
- W4386826570 hasAuthorship W4386826570A5048498264 @default.
- W4386826570 hasAuthorship W4386826570A5062788756 @default.
- W4386826570 hasAuthorship W4386826570A5066155047 @default.
- W4386826570 hasAuthorship W4386826570A5070486070 @default.
- W4386826570 hasAuthorship W4386826570A5080163279 @default.
- W4386826570 hasAuthorship W4386826570A5091013824 @default.
- W4386826570 hasBestOaLocation W43868265701 @default.
- W4386826570 hasConcept C126322002 @default.
- W4386826570 hasConcept C181199279 @default.
- W4386826570 hasConcept C186738567 @default.
- W4386826570 hasConcept C203014093 @default.
- W4386826570 hasConcept C2776217839 @default.
- W4386826570 hasConcept C2777151630 @default.
- W4386826570 hasConcept C2778248108 @default.
- W4386826570 hasConcept C2778382381 @default.
- W4386826570 hasConcept C2778837598 @default.
- W4386826570 hasConcept C2779703530 @default.
- W4386826570 hasConcept C502942594 @default.
- W4386826570 hasConcept C55493867 @default.
- W4386826570 hasConcept C71924100 @default.
- W4386826570 hasConcept C86803240 @default.
- W4386826570 hasConcept C95444343 @default.
- W4386826570 hasConceptScore W4386826570C126322002 @default.
- W4386826570 hasConceptScore W4386826570C181199279 @default.
- W4386826570 hasConceptScore W4386826570C186738567 @default.
- W4386826570 hasConceptScore W4386826570C203014093 @default.
- W4386826570 hasConceptScore W4386826570C2776217839 @default.
- W4386826570 hasConceptScore W4386826570C2777151630 @default.
- W4386826570 hasConceptScore W4386826570C2778248108 @default.
- W4386826570 hasConceptScore W4386826570C2778382381 @default.
- W4386826570 hasConceptScore W4386826570C2778837598 @default.
- W4386826570 hasConceptScore W4386826570C2779703530 @default.
- W4386826570 hasConceptScore W4386826570C502942594 @default.
- W4386826570 hasConceptScore W4386826570C55493867 @default.
- W4386826570 hasConceptScore W4386826570C71924100 @default.
- W4386826570 hasConceptScore W4386826570C86803240 @default.
- W4386826570 hasConceptScore W4386826570C95444343 @default.
- W4386826570 hasLocation W43868265701 @default.
- W4386826570 hasOpenAccess W4386826570 @default.
- W4386826570 hasPrimaryLocation W43868265701 @default.
- W4386826570 hasRelatedWork W1969762152 @default.
- W4386826570 hasRelatedWork W2023747882 @default.
- W4386826570 hasRelatedWork W2028185878 @default.
- W4386826570 hasRelatedWork W2160451402 @default.
- W4386826570 hasRelatedWork W2292166084 @default.
- W4386826570 hasRelatedWork W2400595989 @default.
- W4386826570 hasRelatedWork W2411147831 @default.
- W4386826570 hasRelatedWork W2473504839 @default.
- W4386826570 hasRelatedWork W2589858167 @default.
- W4386826570 hasRelatedWork W4295127106 @default.
- W4386826570 isParatext "false" @default.
- W4386826570 isRetracted "false" @default.
- W4386826570 workType "article" @default.