Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386827443> ?p ?o ?g. }
- W4386827443 endingPage "126987" @default.
- W4386827443 startingPage "126987" @default.
- W4386827443 abstract "Polysaccharides are known to confer protection against glycolipid metabolism disorders (GMD) by regulating intestinal flora. In this study, a heterogeneous acidic heteropolysaccharide with high molecular weight mainly composed of fructose was isolated from Atractylodes macrocephala Koidz (AMP). Supplementation with AMP was shown to improve diet-induced GMD in a rat model, including decreasing the levels of serum triglycerides, total cholesterol, and glucose, and improving hepatic lipidosis and islet cells morphologies. AMP-treated rats also exhibited modified intestinal flora with enrichments of intestinal Lactobacillus and Rothia species, which was accompanied by increased tryptophan metabolites such as indole-3-propionic acid, indole, tryptamine, and tryptophan. These metabolites promote the expression of intestinal aryl hydrocarbon receptor (AhR) in nuclear fractions. AhR activation increased the expression levels of IL-22 and GLP-1 proteins and mRNA. IL-22 reduced systemic LPS by upregulating the expression of tight junction proteins, antimicrobial peptides, and mucin to ameliorate intestinal barrier function, and activated the hepatic IL-22R/Stat3/Acox1 signaling pathway to improve lipid metabolism. GLP-1 activated the pancreatic GLP-1R/p-CREB signaling pathway to ameliorate β-cell injury and improve insulin resistance. Therefore, the intestinal microbial-tryptophan metabolism-AhR pathway was deduced to be a mechanism by which this polysaccharide improves GMD." @default.
- W4386827443 created "2023-09-19" @default.
- W4386827443 creator A5005848875 @default.
- W4386827443 creator A5017440388 @default.
- W4386827443 creator A5019371675 @default.
- W4386827443 creator A5034730241 @default.
- W4386827443 creator A5034995105 @default.
- W4386827443 creator A5040456231 @default.
- W4386827443 creator A5040747953 @default.
- W4386827443 creator A5061817335 @default.
- W4386827443 creator A5068628266 @default.
- W4386827443 creator A5079382582 @default.
- W4386827443 creator A5084581807 @default.
- W4386827443 creator A5085963164 @default.
- W4386827443 creator A5089921461 @default.
- W4386827443 date "2023-12-01" @default.
- W4386827443 modified "2023-10-01" @default.
- W4386827443 title "Atractylodes macrocephala Koidz polysaccharide improves glycolipid metabolism disorders through activation of aryl hydrocarbon receptor by gut flora-produced tryptophan metabolites" @default.
- W4386827443 cites W1975296949 @default.
- W4386827443 cites W1983552942 @default.
- W4386827443 cites W1995240636 @default.
- W4386827443 cites W2024979614 @default.
- W4386827443 cites W2027645497 @default.
- W4386827443 cites W2040501063 @default.
- W4386827443 cites W2085368670 @default.
- W4386827443 cites W2137068383 @default.
- W4386827443 cites W2150268817 @default.
- W4386827443 cites W2223296199 @default.
- W4386827443 cites W2493278154 @default.
- W4386827443 cites W2795231384 @default.
- W4386827443 cites W2795720999 @default.
- W4386827443 cites W2802744456 @default.
- W4386827443 cites W2807728333 @default.
- W4386827443 cites W2883853179 @default.
- W4386827443 cites W2886401819 @default.
- W4386827443 cites W2887432875 @default.
- W4386827443 cites W2891356918 @default.
- W4386827443 cites W2901968410 @default.
- W4386827443 cites W2910159017 @default.
- W4386827443 cites W2921178811 @default.
- W4386827443 cites W2948344571 @default.
- W4386827443 cites W2969258908 @default.
- W4386827443 cites W2972533507 @default.
- W4386827443 cites W2978061681 @default.
- W4386827443 cites W2983737957 @default.
- W4386827443 cites W2999444015 @default.
- W4386827443 cites W3006365752 @default.
- W4386827443 cites W3009666649 @default.
- W4386827443 cites W3012976530 @default.
- W4386827443 cites W3015057704 @default.
- W4386827443 cites W3033228572 @default.
- W4386827443 cites W3039434235 @default.
- W4386827443 cites W3040774192 @default.
- W4386827443 cites W3043969532 @default.
- W4386827443 cites W3085775790 @default.
- W4386827443 cites W3086876551 @default.
- W4386827443 cites W3092973953 @default.
- W4386827443 cites W3106944720 @default.
- W4386827443 cites W3138129392 @default.
- W4386827443 cites W3155898036 @default.
- W4386827443 cites W3181799617 @default.
- W4386827443 cites W3199456235 @default.
- W4386827443 cites W3202975875 @default.
- W4386827443 cites W3208135638 @default.
- W4386827443 cites W4200012339 @default.
- W4386827443 cites W4200462332 @default.
- W4386827443 cites W4205478049 @default.
- W4386827443 cites W4210347334 @default.
- W4386827443 cites W4212955984 @default.
- W4386827443 cites W4224284255 @default.
- W4386827443 cites W4224950010 @default.
- W4386827443 cites W4282560381 @default.
- W4386827443 cites W4283520445 @default.
- W4386827443 cites W4283759313 @default.
- W4386827443 cites W4283819291 @default.
- W4386827443 cites W4289517035 @default.
- W4386827443 cites W4293879967 @default.
- W4386827443 cites W4307240323 @default.
- W4386827443 cites W4309569879 @default.
- W4386827443 cites W4310672725 @default.
- W4386827443 cites W4312066578 @default.
- W4386827443 cites W4317632967 @default.
- W4386827443 cites W4323532607 @default.
- W4386827443 cites W4378619546 @default.
- W4386827443 cites W4381620517 @default.
- W4386827443 cites W4382199623 @default.
- W4386827443 doi "https://doi.org/10.1016/j.ijbiomac.2023.126987" @default.
- W4386827443 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37729987" @default.
- W4386827443 hasPublicationYear "2023" @default.
- W4386827443 type Work @default.
- W4386827443 citedByCount "0" @default.
- W4386827443 crossrefType "journal-article" @default.
- W4386827443 hasAuthorship W4386827443A5005848875 @default.
- W4386827443 hasAuthorship W4386827443A5017440388 @default.
- W4386827443 hasAuthorship W4386827443A5019371675 @default.
- W4386827443 hasAuthorship W4386827443A5034730241 @default.
- W4386827443 hasAuthorship W4386827443A5034995105 @default.
- W4386827443 hasAuthorship W4386827443A5040456231 @default.