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• W4386827495 abstract "We have studied Danio rerio (Zebrafish) TRPA1 channel using a method that combines single channel electrophysiological and optical recordings to evaluate lateral mobility and channel gating simultaneously in single channels. TRPA1 channel activation by two distinct chemical ligands: allyl isothiocyanate (AITC) and TRPswitch B, results in substantial reduction of channel lateral mobility at the plasma membrane. Incubation with the cholesterol sequestering agent methyl-β-cyclodextrin (MβCD), prevents the reduction on lateral mobility induced by the two chemical agonists. This results strongly suggest that the open conformation of TRPA1 modulates channel lateral mobility probably by facilitating the insertion of the channel into cholesterol-enriched domains at the plasma membrane." @default.
• W4386827495 created "2023-09-19" @default.
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• W4386827495 date "2023-12-01" @default.
• W4386827495 modified "2023-10-16" @default.
• W4386827495 title "The conducting state of TRPA1 modulates channel lateral mobility" @default.
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• W4386827495 doi "https://doi.org/10.1016/j.ceca.2023.102800" @default.
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