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- W4386828346 abstract "The diversity of neural stem cells is a hallmark of the cerebral cortex development in gyrencephalic mammals, such as Primates and Carnivora. Among them, ferrets are a good model for mechanistic studies. However, information on their neural progenitor cells (NPC), termed radial glia (RG), is limited. Here, we surveyed the temporal series of single-cell transcriptomes of progenitors regarding ferret corticogenesis and, found a conserved diversity and temporal trajectory between human and ferret NPC, despite the large timescale difference. We found truncated RG (tRG) in ferret cortical development, a progenitor subtype previously described in humans. The combination of in silico and in vivo analyses identified that tRG differentiate into both ependymal and astrogenic cells. Via transcriptomic comparison, we predict that this is also the case in humans. Our findings suggest that tRG plays a role in the formation of adult ventricles, thereby providing the architectural bases for brain expansion." @default.
- W4386828346 created "2023-09-19" @default.
- W4386828346 creator A5002443691 @default.
- W4386828346 date "2023-09-18" @default.
- W4386828346 modified "2023-09-26" @default.
- W4386828346 title "eLife assessment: Truncated radial glia as a common precursor in the late corticogenesis of gyrencephalic mammals" @default.
- W4386828346 doi "https://doi.org/10.7554/elife.91406.1.sa0" @default.
- W4386828346 hasPublicationYear "2023" @default.
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