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• W4386828488 abstract "Abstract People with osteoarthritis often experience pain and depression. These meta-analyses examined and compared nonpharmacological randomized controlled trials (RCTs) for pain and symptoms of depression in people living with osteoarthritis. RCTs published up until April 2022 were sourced by searching electronic databases EMBASE, PUBMED & MEDLINE, Web of Science, CINAHL and PEDro. Random-effects meta-analyses were performed to calculate pooled effect sizes (ES) and 95% confidence intervals (CI) for pain and depression. Subgroup analyses examined intervention subtypes. For pain, 29 interventions (n = 4382; 65 ± 6.9 years; 70% female), revealed a significant effect on reducing pain (ES = 0.43, 95% CI [0.25, 0.61], p < 0.001). Effect sizes were significant ( p < 0.001) for movement meditation (ES = 0.52; 95% CI [0.35, 0.69]), multimodal approaches (ES = 0.37; 95% CI [0.22, 0.51]), and psychological therapy (ES = 0.21; 95% CI [0.11, 0.31]), and significant ( p = 0.046) for resistance exercise (ES = 0.43, 95% CI [− 0.07, 0.94]. Aerobic exercise alone did not improve pain. For depression, 28 interventions (n = 3377; 63 ± 7.0 years; 69% female), revealed a significant effect on reducing depressive symptoms (ES = 0.29, 95% CI [0.08, 0.49], p < 0.001). Effect sizes were significant for movement meditation (ES = 0.30; 95% CI [0.06, 0.55], p = 0.008) and multimodal interventions (ES = 0.12; 95% CI [0.07, 0.18], p < 0.001). Resistance/aerobic exercise or therapy alone did not improve depressive symptoms. Mind–body approaches were more effective than aerobic/resistance exercise or therapy alone for reducing pain and depression in people with osteoarthritis. Systematic review registration: PROSPERO CRD42022338051." @default.
• W4386828488 created "2023-09-19" @default.
• W4386828488 creator A5025659409 @default.
• W4386828488 creator A5068854836 @default.
• W4386828488 creator A5080177619 @default.
• W4386828488 creator A5091036724 @default.
• W4386828488 creator A5091551954 @default.
• W4386828488 date "2023-09-18" @default.
• W4386828488 modified "2023-09-28" @default.
• W4386828488 title "Nonpharmacological approaches for pain and symptoms of depression in people with osteoarthritis: systematic review and meta-analyses" @default.
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• W4386828488 doi "https://doi.org/10.1038/s41598-023-41709-x" @default.

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