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- W4386831357 abstract "Introduction Liver transplant (LT) is a promising therapeutic option for patients with liver metastases from colorectal cancer (CRLM). The COLT trial is a prospective multicenter parallel trial that compares the outcomes of LT with chemotherapy alone (Triplete trial) in patients with unresectable CRLM. Aim To assess the feasibility and the short term outcomes of the LT arm of the COLT trial. Materials and Methods Inclusion criteria were unresectable CRLM, CEA < 50 ng/mL, response to maximum 2 cycles of chemotherapy, previous radical resection of the primary colorectal tumor, T stage < T3, N stage < N2, RAS and BRAF wild type. After central multidisciplinary discussion, patients were prospectively enrolled in the COLT trial and subsequently enlisted for LT in their referral Center. LT was performed as per local standards as well as subsequent immunosuppressive regimen. Results From November 2018 and June 2023, 34 patients were enrolled at 10 participating Centers. From the time of formal enrolment, 5 patients (14.7%) were excluded from LT: 2 patients for intrahepatic progression and 2 for extrahepatic progression on waiting list, 1 for peritoneal diffusion at explorative laparotomy. Six patients are still on waiting list, and 23 underwent LT within a median waiting time of 46 days (IQR: 25-74). One patient needed re-LT for primary non-function, and subsequently died for multiorgan failure. The remaining 22 patients had a median post-LT hospital stay of 10.5 (IQR:8-20) days and experienced postoperative complication (DCC > II) in 18%. The readmission rate at 90 days was 9%. Within a median follow-up of 17 months, 10 patients experienced tumor recurrence and 14 patients are alive without evidence of disease Conclusions Liver transplant confirms is feasible and safe in the setting of CRLM. There is a significant rate of dropout despite short waiting time, underlying the need of strict selection criteria and ongoing treatments while on waitlist." @default.
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- W4386831357 date "2023-09-01" @default.
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- W4386831357 title "Liver transplantation for metastatic colorectal cancer after optimal systemic treatment (COLT trial): feasibility and safety data" @default.
- W4386831357 doi "https://doi.org/10.1016/j.dld.2023.08.011" @default.
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