Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386833229> ?p ?o ?g. }
- W4386833229 endingPage "370" @default.
- W4386833229 startingPage "353" @default.
- W4386833229 abstract "The angiotensin-converting enzyme (ACE) was discovered in 1956 and has been actively studied to date. It has a unique structure of two homologous domains, each containing a catalytic zinc ion. Domains have different substrate specificity. In terms of function, ACE is a zinc metallopeptidase widely present on the surface of endothelial and epithelial cells. The gene encoding ACE is located on the long arm of chromosome 17 (17q23) and is 21 kb long, including 26 exons and 25 introns. The structure of ACE may be the result of an ancient gene duplication that occurred approximately 700 million years ago. The main function of ACE is the conversion of AngI to the vasoconstrictor AngII, which is the main active product. In addition, ACE metabolizes bradykinin, which is a potent vasodilator. ACE is involved in the metabolism of other angiotensins, in particular Ang(1–7), forming, together with ACE 2 and other components of the renin-angiotensin-aldosterone system (RAAS), a complex balanced system for maintaining blood pressure, water and electrolyte balance, and many other components of systemic, tissue and cellular homeostasis that have not yet been fully studied. More data are accumulating confirming the role of ACE for the renal development, early hematopoiesis, normal male fertility, erythropoiesis, myelopoiesis. ACE plays important roles in the immune response, intracellular signaling." @default.
- W4386833229 created "2023-09-19" @default.
- W4386833229 creator A5046136603 @default.
- W4386833229 date "2023-03-14" @default.
- W4386833229 modified "2023-09-26" @default.
- W4386833229 title "Angiotensin-converting enzyme: a well-known stranger. Part I" @default.
- W4386833229 cites W1495026747 @default.
- W4386833229 cites W1516407063 @default.
- W4386833229 cites W1522513618 @default.
- W4386833229 cites W1527049741 @default.
- W4386833229 cites W1535139368 @default.
- W4386833229 cites W1554181954 @default.
- W4386833229 cites W1578637929 @default.
- W4386833229 cites W1581033551 @default.
- W4386833229 cites W1588015921 @default.
- W4386833229 cites W1606692317 @default.
- W4386833229 cites W1767994247 @default.
- W4386833229 cites W1835826588 @default.
- W4386833229 cites W1839054962 @default.
- W4386833229 cites W1906352940 @default.
- W4386833229 cites W1942364642 @default.
- W4386833229 cites W195015772 @default.
- W4386833229 cites W1964209840 @default.
- W4386833229 cites W1964662138 @default.
- W4386833229 cites W1964696346 @default.
- W4386833229 cites W1966315087 @default.
- W4386833229 cites W1966339428 @default.
- W4386833229 cites W1966973320 @default.
- W4386833229 cites W1967166817 @default.
- W4386833229 cites W1967632907 @default.
- W4386833229 cites W1967891478 @default.
- W4386833229 cites W1968256336 @default.
- W4386833229 cites W1969282066 @default.
- W4386833229 cites W1970068637 @default.
- W4386833229 cites W1970108358 @default.
- W4386833229 cites W1971467647 @default.
- W4386833229 cites W1972221458 @default.
- W4386833229 cites W1974901207 @default.
- W4386833229 cites W1975304753 @default.
- W4386833229 cites W1977466782 @default.
- W4386833229 cites W1985104380 @default.
- W4386833229 cites W1985376983 @default.
- W4386833229 cites W1985545066 @default.
- W4386833229 cites W1987444143 @default.
- W4386833229 cites W1987518625 @default.
- W4386833229 cites W1987586914 @default.
- W4386833229 cites W1987893360 @default.
- W4386833229 cites W1988742001 @default.
- W4386833229 cites W1988799768 @default.
- W4386833229 cites W1990840149 @default.
- W4386833229 cites W1993458839 @default.
- W4386833229 cites W1999061258 @default.
- W4386833229 cites W2002034335 @default.
- W4386833229 cites W2003870922 @default.
- W4386833229 cites W2004819111 @default.
- W4386833229 cites W2004840558 @default.
- W4386833229 cites W2015141049 @default.
- W4386833229 cites W2018119516 @default.
- W4386833229 cites W2018281361 @default.
- W4386833229 cites W2019591778 @default.
- W4386833229 cites W2020177273 @default.
- W4386833229 cites W2021634281 @default.
- W4386833229 cites W2022324445 @default.
- W4386833229 cites W2025196218 @default.
- W4386833229 cites W2028439883 @default.
- W4386833229 cites W2029190141 @default.
- W4386833229 cites W2033565692 @default.
- W4386833229 cites W2036286953 @default.
- W4386833229 cites W2036409899 @default.
- W4386833229 cites W2036894466 @default.
- W4386833229 cites W2040418189 @default.
- W4386833229 cites W2043200338 @default.
- W4386833229 cites W2043721542 @default.
- W4386833229 cites W2055496662 @default.
- W4386833229 cites W2055835158 @default.
- W4386833229 cites W2057874793 @default.
- W4386833229 cites W2059287255 @default.
- W4386833229 cites W2060050520 @default.
- W4386833229 cites W2061520576 @default.
- W4386833229 cites W2062083219 @default.
- W4386833229 cites W2065631010 @default.
- W4386833229 cites W2068488537 @default.
- W4386833229 cites W2068932067 @default.
- W4386833229 cites W2070663530 @default.
- W4386833229 cites W2072715364 @default.
- W4386833229 cites W2074171851 @default.
- W4386833229 cites W2076669998 @default.
- W4386833229 cites W2077999719 @default.
- W4386833229 cites W2087584879 @default.
- W4386833229 cites W2089025918 @default.
- W4386833229 cites W2093447253 @default.
- W4386833229 cites W2093736722 @default.
- W4386833229 cites W2094865036 @default.
- W4386833229 cites W2097051773 @default.
- W4386833229 cites W2097334774 @default.
- W4386833229 cites W2102985891 @default.
- W4386833229 cites W2105942948 @default.
- W4386833229 cites W2107995915 @default.