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- W4386836173 abstract "The development of acquired resistance to anti-EGFR therapies remains poorly understood, with most research to date exploring, and trying to overcome, various genomic mechanisms of resistance. However, recent work supports a model of resistance whereby transcriptomic mechanisms of resistance predominate in the presence of active cytotoxic chemotherapy combined with anti-EGFR therapy in the first-line setting, with a greater predominance of acquired MAPK mutations after single-agent anti-EGFR therapy in the later-line setting. The proposed model has implications for prospective studies evaluating anti-EGFR rechallenge strategies guided by acquired MAPK mutations and highlights the need to address transcriptional mechanisms of resistance." @default.
- W4386836173 created "2023-09-19" @default.
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- W4386836173 date "2023-09-15" @default.
- W4386836173 modified "2023-10-05" @default.
- W4386836173 title "Mechanisms of resistance to EGFR-targeted therapies in colorectal cancer: more than just genetics" @default.
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- W4386836173 doi "https://doi.org/10.3389/fcell.2023.1176657" @default.
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